Talk:Insulin lispro

Absorption statement misleading?

The first para says "Onset of effects typically occurs within 30 minutes and lasts about 5 hours". I understand this to be true in general but also rather alarming, as having been prescribed Lyumljev as a fast-acting insulin. Only after reading did I find that some lispro variants have additional ingredients to accelerate absorption. Marinheiro (talk) 17:47, 7 January 2025 (UTC)

Comments

"Engineered through recombinant DNA technology, the penultimate lysine and proline residues on the C-terminal end of the B-chain are reversed. This modification does not alter receptor binding..."

According to the scholarly journal article, Correlations of Receptor Binding and Metabolic and Mitogenic Potencies of Insulin Analogs Designed for Clinical Use, by Peter Kurtzhals, Lauge Schäffer, Anders Sørensen, Claus Kristensen, Ib Jonassen, Christoph Schmid, and Thomas Trüb, published in Diabetes June 2000 vol. 49 no. 6 pp. 999-1005, insulin lispro has different receptor binding properties than normal human insulin:

It's insulin receptor affinity is 84% (± 6%) of human insulin, and its Insulin-Like Growth Factor 1 receptor affinity is 156% (± 16%) of human insulin.

The statement "...does not alter receptor binding..." is a misleading generalization.

205.118.82.151 (talk) 22:14, 30 September 2010 (UTC)

What is the make of the clear material that the insulin is immersed in?

I understand that plastic eroding by insulin (I use Humalog Lispro) is actually caused by the stuff it's immersed and dissolved in. What is it?פשוט pashute ♫ (talk) 17:51, 4 September 2017 (UTC)