// Workers AI · dad joke modeWhat did STYXL1 say to its date? Styx and stones may break my heart.

STYXL1
Identifiers
Aliases	STYXL1, DUSP24, MK-STYX, MKSTYX, serine/threonine/tyrosine interacting-like 1, serine/threonine/tyrosine interacting like 1
External IDs	OMIM: 616695; MGI: 1923821; GeneCards: STYXL1
Gene location (Human)
Chr.	Chromosome 7 (human)
End	76,048,004 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	135,807,239 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; mucosa of transverse colon; ; islet of Langerhans; ; granulocyte; ; monocyte; ; body of pancreas; ; rectum; ; olfactory zone of nasal mucosa; ; nasal epithelium; ; epithelium of bronchus;
	Top expressed in
	spermatid; ; seminiferous tubule; ; spermatocyte; ; granulocyte; ; embryo; ; blastocyst; ; lumbar spinal ganglion; ; morula; ; right kidney; ; medial ganglionic eminence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hydrolase activity; protein tyrosine/serine/threonine phosphatase activity; phosphoprotein phosphatase activity; pseudophosphatase activity; protein phosphatase inhibitor activity; protein binding; protein phosphatase binding;
Cellular component	mitochondrion; mitochondrial matrix;
Biological process	intracellular signal transduction; protein dephosphorylation; dephosphorylation; positive regulation of neuron projection development; negative regulation of phosphoprotein phosphatase activity; regulation of intrinsic apoptotic signaling pathway; positive regulation of intrinsic apoptotic signaling pathway; negative regulation of stress granule assembly;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	51657
	76571
	ENSG00000127952
	ENSMUSG00000019178
	Q9Y6J8
	n/a
NM_016086; NM_001317785; NM_001317786; NM_001317787; NM_001317788;
	NM_001317789
	NM_001289554; NM_001289555; NM_001289556; NM_001289557; NM_029659
NP_001304714; NP_001304715; NP_001304716; NP_001304717; NP_001304718;
	NP_057170
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine/tyrosine-interacting-like protein 1 is a protein, encoded in humans by the STYXL1 gene (previously DUSP24).^[5]^[6] It is a phosphatase-like protein that is no longer able to act as an enzyme.^[7] Instead, it binds to proteins like G3BP1 and PTPMT1 and inhibits certain activities.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000127952 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019178 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wishart MJ, Dixon JE (Oct 1998). "Gathering STYX: phosphatase-like form predicts functions for unique protein-interaction domains". Trends Biochem Sci. 23 (8): 301–6. doi:10.1016/S0968-0004(98)01241-9. PMID 9757831.
↑ "Entrez Gene: STYXL1 serine/threonine/tyrosine interacting-like 1".
1 2 "Q9Y6J8 · STYL1_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-14.

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Cheng J, Kapranov P, Drenkow J, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. Bibcode:2005Sci...308.1149C. doi:10.1126/science.1108625. PMID 15790807. S2CID 13047538.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Siligan C, Ban J, Bachmaier R, et al. (2005). "EWS-FLI1 target genes recovered from Ewing's sarcoma chromatin". Oncogene. 24 (15): 2512–24. doi:10.1038/sj.onc.1208455. PMID 15735734.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000127952 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019178 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9757831-5] Wishart MJ, Dixon JE (Oct 1998). "Gathering STYX: phosphatase-like form predicts functions for unique protein-interaction domains". Trends Biochem Sci. 23 (8): 301–6. doi:10.1016/S0968-0004(98)01241-9. PMID 9757831.

[entrez-6] "Entrez Gene: STYXL1 serine/threonine/tyrosine interacting-like 1".

[uniprot-7] 1 2 "Q9Y6J8 · STYL1_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-14.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

References

Further reading