// Workers AI · dad joke modeWhat did PTBP2 say to its friend? "Let's bind together.

PTBP2
Identifiers
Aliases	PTBP2, PTBLP, brPTB, nPTB, polypyrimidine tract binding protein 2
External IDs	OMIM: 608449; MGI: 1860489; HomoloGene: 23162; GeneCards: PTBP2; OMA:PTBP2 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CQ1, 2MJU, 4CQ1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	96,823,738 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	119,578,115 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; corpus callosum; ; ventricular zone; ; Achilles tendon; ; pars compacta; ; gastric mucosa; ; secondary oocyte; ; pars reticulata; ; testicle; ; muscle layer of sigmoid colon;
	Top expressed in
	spermatocyte; ; genital tubercle; ; medial ganglionic eminence; ; tail of embryo; ; pineal gland; ; superior cervical ganglion; ; ventricular zone; ; ventral tegmental area; ; ventromedial nucleus; ; maxillary prominence;
	More reference expression data
	n/a
Gene ontology
Molecular function	mRNA binding; pre-mRNA binding; nucleic acid binding; RNA binding;
Cellular component	growth cone; spliceosomal complex; soma; nucleus;
Biological process	mRNA splice site selection; cerebellum development; mRNA processing; RNA splicing; spinal cord development; regulation of neural precursor cell proliferation; negative regulation of RNA splicing;
	Sources:Amigo / QuickGO
Orthologs
	58155
	56195
	ENSG00000117569
	ENSMUSG00000028134
	Q9UKA9
	Q91Z31
NM_001300985; NM_001300986; NM_001300987; NM_001300988; NM_001300989;
	NM_001300990; NM_021190
	NM_019550; NM_001310711
NP_001287914; NP_001287915; NP_001287916; NP_001287917; NP_001287918;
	NP_001287919; NP_067013
	NP_001297640; NP_062423
	Wikidata
View/Edit Human	View/Edit Mouse

Polypyrimidine tract binding protein 2, also known as PTBP2, is a protein which in humans is encoded by the PTBP2 gene.^[5]^[6]

Function

The protein encoded by this gene binds to the intronic cluster of RNA regulatory elements, downstream control sequence (DCS). It is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract-binding protein PTBP1 but it is expressed primarily in the brain.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000117569 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028134 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Markovtsov V, Nikolic JM, Goldman JA, Turck CW, Chou MY, Black DL (October 2000). "Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein". Mol. Cell. Biol. 20 (20): 7463–79. doi:10.1128/MCB.20.20.7463-7479.2000. PMC 86300. PMID 11003644.
1 2 "Entrez Gene: PTBP2 polypyrimidine tract binding protein 2".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000117569 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028134 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11003644-5] Markovtsov V, Nikolic JM, Goldman JA, Turck CW, Chou MY, Black DL (October 2000). "Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein". Mol. Cell. Biol. 20 (20): 7463–79. doi:10.1128/MCB.20.20.7463-7479.2000. PMC 86300. PMID 11003644.

[entrez-6] 1 2 "Entrez Gene: PTBP2 polypyrimidine tract binding protein 2".

[1]

[2]

[3]

[4]

[5]

[6]