// Workers AI · dad joke modeWhat did Libiguin A say to its friend? "Let's bond.
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| Clinical data | |
|---|---|
| Drug class | Pro-sexual agent |
| ATC code |
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| Chemical and physical data | |
| Formula | C37H46O13 |
| Molar mass | 698.762 g·mol−1 |
| 3D model (JSmol) | |
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Libiguin A is a naturally occurring limonoid found in Neobeguea mahafalensis, a flowering plant found in Madagascar with a long history of traditional medical use.[1][2][3][4][5] It is a derivative of phragmalin.[1] The compound has been reported to produce highly potent, strong, and long-lasting pro-sexual effects in rodents.[1][5] The semisynthesis of libiguin A from phragmalin has been described.[2] An analogue also found in Neobeguea mahafalensis, libiguin B, has similar pro-sexual effects but is far less potent in comparison.[1][2][5] Another analogue, a synthetic compound known as volufralin (LIB-01; DIC-2024), is under development for the treatment of erectile dysfunction and premature ejaculation.[6][7] Libiguin A was first described in the scientific literature by 2014.[1][2]
See also
[edit]References
[edit]- 1 2 3 4 5 Razafimahefa S, Mutulis F, Mutule I, Liepinsh E, Dambrova M, Cirule H, et al. (March 2014). "Libiguins A and B: novel phragmalin limonoids isolated from Neobeguea mahafalensis causing profound enhancement of sexual activity". Planta Medica. 80 (4): 306–314. doi:10.1055/s-0033-1360390. PMID 24549927.
- 1 2 3 4 Grigorjeva L, Liepinsh E, Razafimahefa S, Yahorau A, Yahorava S, Rasoanaivo P, et al. (May 2014). "Semisynthesis of libiguin A and its analogues by trans-lactonization of phragmalin". The Journal of Organic Chemistry. 79 (9): 4148–4153. doi:10.1021/jo500318w. PMID 24716657.
- ↑ Fossen T, Yahorau A, Yahorava S, Raharinjato F, Razafimahefa S, Rasoanaivo P, et al. (July 2016). "New Polyfunctional Phragmalin Limonoids from Neobeguea mahafalensis". Planta Medica. 82 (11–12): 1087–1095. doi:10.1055/s-0042-108741. PMID 27340794.
- ↑ Zhang Y, Xu H (2017). "Recent progress in the chemistry and biology of limonoids". RSC Advances. 7 (56): 35191–35220. doi:10.1039/c7ra04715k. ISSN 2046-2069.
3.1.14. Neobeguea. As described in Fig. 15, 11 new limonoids, namely, dodoguin 313, dormir A–G 314–320, 108 libiguins A 321, libiguins B (a) 322 and libiguins B (b) 323, 109 were isolated from the root barks of Neobeguea mahafalensis, a medicinal plant in Madagascar. Interestingly, compounds 318, and 321–323 contained a C-16/30 d-lactone ring, which was the rst time reported in this species. [...] compound 322 exhibited a potent sexual enhancing activity.
- 1 2 3 Hill RA, Connolly JD (December 2018). "Triterpenoids". Natural Product Reports. 35 (12): 1294–1329. doi:10.1039/c8np00029h. PMID 29993074.
Neobeguea mahafalensis is the source of the phragmalin derivatives libiguin A 560 and libiguin B 561 (in equilibrium with its keto tautomer).202 These compounds are reported to have aphrodisiac properties.
- ↑ "LIB 01". AdisInsight. 26 December 2025. Retrieved 27 January 2026.
- ↑ Foster B (12 January 2026). "A new approach could radically change erectile dysfunction treatment". Drug Discovery News. Retrieved 27 January 2026.