// Workers AI · dad joke modeWhat did KRT76 say to its date? You're a great byte.

KRT76
Identifiers
Aliases	KRT76, HUMCYT2A, KRT2B, KRT2P, keratin 76
External IDs	OMIM: 616671; MGI: 1924305; GeneCards: KRT76
Gene location (Human)
Chr.	Chromosome 12 (human)
End	52,777,345 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	101,801,355 bp
RNA expression pattern
	Top expressed in
	gums; ; gingival epithelium; ; body of tongue; ; superior surface of tongue; ; cervix epithelium; ; pharynx; ; tonsil; ; mucosa of esophagus; ; apex of heart; ; exocrine gland;
	Top expressed in
	embryo; ; molar; ; esophagus; ; zygote; ; oocyte; ; secondary oocyte; ; primary oocyte; ; lip; ; sexually immature organism; ; blood;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural molecule activity;
Cellular component	keratin filament; intermediate filament; extracellular exosome; nucleus; cytosol;
Biological process	sebaceous gland development; cytoskeleton organization; epidermis development; keratinization; pigmentation; cornification;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	51350
	77055
	ENSG00000185069
	ENSMUSG00000075402
	Q01546
	Q3UV17
	NM_015848
	NM_001033177
	NP_056932
	NP_001028349
	Wikidata
View/Edit Human	View/Edit Mouse

Keratin, type II cytoskeletal 2 oral is a protein that in humans is encoded by the KRT76 gene. Loss of this gene's expression or downregulation of the gene is associated with oral cancer.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000185069 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000075402 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ambatipudi S, Bhosale PG, Heath E, Pandey M, Kumar G, Kane S, et al. (30 July 2013). "Downregulation of keratin 76 expression during oral carcinogenesis of human, hamster and mouse". PLOS ONE. 8 (7) e70688. Bibcode:2013PLoSO...870688A. doi:10.1371/journal.pone.0070688. PMC 3728316. PMID 23936238.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000185069 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000075402 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Ambatipudi S, Bhosale PG, Heath E, Pandey M, Kumar G, Kane S, et al. (30 July 2013). "Downregulation of keratin 76 expression during oral carcinogenesis of human, hamster and mouse". PLOS ONE. 8 (7) e70688. Bibcode:2013PLoSO...870688A. doi:10.1371/journal.pone.0070688. PMC 3728316. PMID 23936238.

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