// Workers AI · dad joke modeWhat did GMPPB say to its date? You're a great match.

GMPPB
Identifiers
Aliases	GMPPB, MDDGA14, MDDGB14, MDDGC14, GDP-mannose pyrophosphorylase B, LGMDR19
External IDs	OMIM: 615320; MGI: 2660880; GeneCards: GMPPB
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.7.7.13 ↗ ↗ ↗ ↗
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 F1 Start 107,926,441 bp End 107,930,000 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas anterior pituitary bone marrow cell right lobe of thyroid gland minor salivary glands right lobe of liver left lobe of thyroid gland right adrenal gland left adrenal gland body of stomach Top expressed in epithelium of small intestine intestinal villus Ileal epithelium jejunum duodenum islet of Langerhans spermatid proximal tubule placenta colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity mannose-1-phosphate guanylyltransferase activity nucleotide binding nucleotidyltransferase activity GTP binding protein binding Cellular component cytoplasm Biological process biosynthesis GDP-mannose biosynthetic process Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry Species Human Mouse Entrez 29925 331026 Ensembl n/a ENSMUSG00000070284 UniProt Q9Y5P6 Q8BTZ7 RefSeq (mRNA) NM_021971 NM_013334 NM_177910 NM_001357682 RefSeq (protein) NP_037466 NP_068806 NP_808578 NP_001344611 Location (UCSC) n/a Chr 9: 107.93 – 107.93 Mb PubMed search
Wikidata
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Mannose-1-phosphate guanyltransferase beta is an enzyme that in humans is encoded by the GMPPB gene.

This gene is thought to encode a GDP-mannose pyrophosphorylase. This enzyme catalyzes the reaction which converts mannose-1-phosphate and GTP to GDP-mannose which is involved in the production of N-linked oligosaccharides. The gene encodes two transcript variants.

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ono T, Sekino-Suzuki N, Kikkawa Y, et al. (2003). "Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons". J. Neurosci. 23 (13): 5887–96. doi:10.1523/JNEUROSCI.23-13-05887.2003. PMC 6741272. PMID 12843293.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
• Ning B, Elbein AD (2001). "Cloning, expression and characterization of the pig liver GDP-mannose pyrophosphorylase. Evidence that GDP-mannose and GDP-Glc pyrophosphorylases are different proteins". Eur. J. Biochem. 267 (23): 6866–74. doi:10.1046/j.1432-1033.2000.01781.x. PMID 11082198.