// Workers AI · dad joke modeWhat did FUT4 say to its date? You're 4-getful.

FUT4
Identifiers
Aliases	FUT4, CD15, ELFT, FCT3A, FUC-TIV, FUTIV, LeX, SSEA-1, fucosyltransferase 4
External IDs	OMIM: 104230; MGI: 95594; GeneCards: FUT4
Enzyme activity
Gene location (Human)
Chr.	Chromosome 11 (human)
End	94,549,895 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	14,663,689 bp
RNA expression pattern
	Top expressed in
	mucosa of sigmoid colon; ; bone marrow; ; mucosa of ileum; ; trabecular bone; ; monocyte; ; bone marrow cell; ; jejunal mucosa; ; duodenum; ; gonad; ; rectum;
	Top expressed in
	left colon; ; Paneth cell; ; epithelium of stomach; ; duodenum; ; granulocyte; ; seminal vesicula; ; transitional epithelium of urinary bladder; ; jejunum; ; mesenteric lymph nodes; ; conjunctival fornix;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; fucosyltransferase activity; glycosyltransferase activity; alpha-(1->3)-fucosyltransferase activity;
Cellular component	integral component of membrane; Golgi cisterna membrane; cell surface; Golgi apparatus; membrane; cell periphery; Golgi membrane;
Biological process	protein glycosylation; fucosylation; L-fucose catabolic process; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	2526
	14345
	ENSG00000196371
	ENSMUSG00000049307
	P22083
	Q11127
	NM_002033
	NM_010242
	NP_002024
	NP_034372
	Wikidata
View/Edit Human	View/Edit Mouse

Fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific), also known as FUT4, is an enzyme which in humans is encoded by the FUT4 gene.^[5]^[6]^[7]

Function

The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15).^[8]^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000196371 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049307 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Goelz SE, Hession C, Goff D, Griffiths B, Tizard R, Newman B, Chi-Rosso G, Lobb R (December 1990). "ELFT: a gene that directs the expression of an ELAM-1 ligand". Cell. 63 (6): 1349–56. doi:10.1016/0092-8674(90)90430-M. PMID 1702034. S2CID 905332.
↑ Couillin P, Mollicone R, Grisard MC, Gibaud A, Ravisé N, Feingold J, Oriol R (1991). "Chromosome 11q localization of one of the three expected genes for the human alpha-3-fucosyltransferases, by somatic hybridization". Cytogenet. Cell Genet. 56 (2): 108–11. doi:10.1159/000133061. PMID 1672847.
↑ Reguigne I, James MR, Richard CW, Mollicone R, Seawright A, Lowe JB, Oriol R, Couillin P (1994). "The gene encoding myeloid alpha-3-fucosyl-transferase (FUT4) is located between D1 1S388 and D11S919 on 11q21". Cytogenet. Cell Genet. 66 (2): 104–6. doi:10.1159/000133677. PMID 8287679.
↑ "Entrez Gene: FUT4".
↑ Nakayama F, Nishihara S, Iwasaki H, Kudo T, Okubo R, Kaneko M, Nakamura M, Karube M, Sasaki K, Narimatsu H (May 2001). "CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV". J. Biol. Chem. 276 (19): 16100–6. doi:10.1074/jbc.M007272200. PMID 11278338.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000196371 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049307 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1702034-5] Goelz SE, Hession C, Goff D, Griffiths B, Tizard R, Newman B, Chi-Rosso G, Lobb R (December 1990). "ELFT: a gene that directs the expression of an ELAM-1 ligand". Cell. 63 (6): 1349–56. doi:10.1016/0092-8674(90)90430-M. PMID 1702034. S2CID 905332.

[pmid1672847-6] Couillin P, Mollicone R, Grisard MC, Gibaud A, Ravisé N, Feingold J, Oriol R (1991). "Chromosome 11q localization of one of the three expected genes for the human alpha-3-fucosyltransferases, by somatic hybridization". Cytogenet. Cell Genet. 56 (2): 108–11. doi:10.1159/000133061. PMID 1672847.

[pmid8287679-7] Reguigne I, James MR, Richard CW, Mollicone R, Seawright A, Lowe JB, Oriol R, Couillin P (1994). "The gene encoding myeloid alpha-3-fucosyl-transferase (FUT4) is located between D1 1S388 and D11S919 on 11q21". Cytogenet. Cell Genet. 66 (2): 104–6. doi:10.1159/000133677. PMID 8287679.

[entrez-8] "Entrez Gene: FUT4".

[pmid11278338-9] Nakayama F, Nishihara S, Iwasaki H, Kudo T, Okubo R, Kaneko M, Nakamura M, Karube M, Sasaki K, Narimatsu H (May 2001). "CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV". J. Biol. Chem. 276 (19): 16100–6. doi:10.1074/jbc.M007272200. PMID 11278338.

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Function

See also

References