// Workers AI · dad joke modeWhat did EAPP say to its friend? "You app-eal to me

EAPP
Identifiers
Aliases	EAPP, BM036, C14orf11, E2F associated phosphoprotein
External IDs	OMIM: 609486; MGI: 1913516; GeneCards: EAPP
Gene location (Human)
Chr.	Chromosome 14 (human)
End	34,539,704 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	54,742,682 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; palpebral conjunctiva; ; olfactory zone of nasal mucosa; ; rectum; ; mucosa of transverse colon; ; skin of leg; ; left ovary; ; skin of abdomen; ; white blood cell; ; ganglionic eminence;
	Top expressed in
	interventricular septum; ; yolk sac; ; medial ganglionic eminence; ; morula; ; seminiferous tubule; ; otic placode; ; epithelium of lens; ; granulocyte; ; neural tube; ; otic vesicle;
	More reference expression data
	More reference expression data
Orthologs
Databases	NCBI: entry; OMA: entry
	55837
	66266
	ENSG00000129518
	ENSMUSG00000054302
	Q56P03
	Q5BU09
	NM_018453; NM_001318916
	NM_025456; NM_001331162
	NP_001305845; NP_060923
	NP_001318091; NP_079732
	Wikidata
View/Edit Human	View/Edit Mouse

E2F-associated phosphoprotein is a protein that in humans is encoded by the EAPP gene.^[5]^[6]

This gene encodes a phosphoprotein that interacts with several members of the E2F family of proteins. The protein localizes to the nucleus, and is present throughout the cell cycle except during mitosis. It functions to modulate E2F-regulated transcription and stimulate proliferation.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000129518 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000054302 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Novy M, Pohn R, Andorfer P, Novy-Weiland T, Galos B, Schwarzmayr L, Rotheneder H (Apr 2005). "EAPP, a novel E2F binding protein that modulates E2F-dependent transcription". Mol Biol Cell. 16 (5): 2181–90. doi:10.1091/mbc.E04-11-0975. PMC 1087227. PMID 15716352.
1 2 "Entrez Gene: C14orf11 chromosome 14 open reading frame 11".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kamnasaran D, Chen CP, Devriendt K, et al. (2005). "Defining a holoprosencephaly locus on human chromosome 14q13 and characterization of potential candidate genes". Genomics. 85 (5): 608–21. doi:10.1016/j.ygeno.2005.01.010. PMID 15820313.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000129518 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000054302 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15716352-5] Novy M, Pohn R, Andorfer P, Novy-Weiland T, Galos B, Schwarzmayr L, Rotheneder H (Apr 2005). "EAPP, a novel E2F binding protein that modulates E2F-dependent transcription". Mol Biol Cell. 16 (5): 2181–90. doi:10.1091/mbc.E04-11-0975. PMC 1087227. PMID 15716352.

[entrez-6] 1 2 "Entrez Gene: C14orf11 chromosome 14 open reading frame 11".

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References

Further reading