Draft:Eric Bachelder
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Eric M. Bachelder | |
|---|---|
| Education | Michigan State University (B.S.) University of Nebraska–Lincoln (Ph.D.) University of California, Berkeley (Postdoctoral) |
| Known for | Invention of acetalated dextran |
| Scientific career | |
| Fields | Chemical engineering, Biomaterials, Immunoengineering, Drug delivery |
| Institutions | University of North Carolina at Chapel Hill |
| Polly Matzinger | |
Other academic advisors | Jean M. J. Fréchet (postdoctoral) |
Eric M. Bachelder is an American chemical engineer and Associate Professor in the Division of Pharmacoengineering and Molecular Pharmaceutics at the UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill. He is known for inventing acetalated dextran (Ace-DEX), a biodegradable, acid-labile polymer widely used in vaccine and drug delivery research.[1] As of 2026, the original paper describing Ace-DEX has been cited over 560 times and is the subject of multiple reviews.[2][3] This work was patented as a modified polyhydroxylated polymer for acid-degradable drug and antigen delivery, with Bachelder listed as a co-inventor alongside Jean Fréchet, Tristan Beaudette, and Kyle Broaders.[4]
Education
[edit]Bachelder earned a Bachelor of Science degree in chemical engineering from Michigan State University, where he conducted undergraduate research on post-harvest distillation under Professor Kris Berglund, a University Distinguished Professor known for his work in fermentation and distillation technologies.[5][6][7]
He went on to complete a Ph.D. in chemical and biomolecular engineering at the University of Nebraska–Lincoln, training in the laboratory of immunologist Polly Matzinger at the National Institutes of Health as a predoctoral Intramural Research Training Award (IRTA) fellow.[5][8][9]
He subsequently completed postdoctoral training at the University of California, Berkeley under Jean M. J. Fréchet, where he developed acetalated dextran as a tunable, acid-degradable biomaterial for particulate immunotherapy.[10]
Research
[edit]Bachelder's research centers on the design of acid-degradable and immunomodulatory biomaterials, particularly acetalated dextran-based micro- and nanoparticles, for controlled delivery of vaccine antigens and adjuvants. His work has contributed to platforms for influenza and other infectious disease vaccines, as well as cancer immunotherapy and tolerance induction for autoimmune conditions.[3][11][12][13]
Patents
[edit]Bachelder holds multiple patents related to acetalated dextran and its use in drug and vaccine delivery systems, originating from work performed during his postdoctoral research at UC Berkeley.[4]
References
[edit]- ↑ Bachelder, Eric M.; Beaudette, Tristan T.; Broaders, Kevin E.; Dashe, Jamie; Fréchet, Jean M. J. (2008). "Acetal-Derivatized Dextran: An Acid-Responsive Biodegradable Material for Therapeutic Applications". Journal of the American Chemical Society. 130 (32): 10494–10495. Bibcode:2008JAChS.13010494B. doi:10.1021/ja803947s. PMC 2673804. PMID 18630909.
- ↑ Bachelder, Eric M.; Beaudette, Tristan T.; Broaders, Kyle E.; Dashe, Jesse; Fréchet, Jean M. J. (2008). "Acetal-Derivatized Dextran: An Acid-Responsive Biodegradable Material for Therapeutic Applications". Journal of the American Chemical Society. 130 (32). Google Scholar: 10494–10495. Bibcode:2008JAChS.13010494B. doi:10.1021/ja803947s. PMC 2673804. PMID 18630909. Retrieved 2026-07-25.
- 1 2 Bachelder, Eric M.; Pino, Erica N.; Ainslie, Kristy M. (2017). "Acetalated Dextran: A Tunable and Acid-Labile Biopolymer for Drug Delivery". Chemical Reviews. 117 (3): 1915–1926. doi:10.1021/acs.chemrev.6b00532. PMID 28032507.
- 1 2 US 10995156B2, Fréchet; Bachelder & Beaudette et al., "Acid-degradable and bioerodible modified polyhydroxylated materials", issued 2021-05-04, assigned to The Regents of the University of California
- 1 2 "CV – Eric M. Bachelder" (PDF). UNC Eshelman School of Pharmacy.
- ↑ "Remembering Kris Berglund". Michigan State University College of Engineering. January 17, 2019.
- ↑ "Obituary: Kris Berglund". Chemical & Engineering News. American Chemical Society.
- ↑ Bachelder, Eric M.; Matzinger, Polly; Velander, William (2004). Oral Delivery of Factor IX. American Institute of Chemical Engineers (AIChE) National Meeting. Austin, TX.
- ↑ "Chemical and Biomolecular Engineering (PhD)". University of Nebraska–Lincoln Graduate Studies.
- ↑ Broaders, Kevin E.; Cohen, Jacques A.; Beaudette, Tristan T.; Bachelder, Eric M.; Fréchet, Jean M. J. (2009). "Acetalated dextran is a chemically and biologically tunable material for particulate immunotherapy". Proceedings of the National Academy of Sciences. 106 (14): 5497–5502. Bibcode:2009PNAS..106.5497B. doi:10.1073/pnas.0901592106. PMC 2666992. PMID 19321415.
- ↑ Wang, Shiqi; Fontana, Flavia; Shahbazi, Mohammad-Ali; Santos, Hélder A. (2021). "Acetalated dextran based nano- and microparticles: synthesis, fabrication, and therapeutic applications". Chemical Communications. 57 (35): 4212–4229. doi:10.1039/D1CC00811K. PMID 33913978.
- ↑ Damus, Branden Joshua; Amaeze, Nzube Ruth; Yoo, Eunsoo; Kaur, Gagandeep (2024). "Ethoxy Acetalated Dextran-Based Biomaterials for Therapeutic Applications". Polymers. 16 (19): 2756. doi:10.3390/polym16192756. PMC 11479160. PMID 39408467.
- ↑ Williamson, Grace L.; Middleton, Denzel D.; Ainslie, Kristy M.; Bachelder, Eric M. (2024). "Acetalated dextran: a novel delivery platform for particle-based vaccines". Expert Opinion on Drug Delivery. 22 (1): 1–5. doi:10.1080/17425247.2024.2442671. PMC 12996827. PMID 39709953.