// Workers AI · dad joke modeWhat did DLGAP3 say to its date? "You gap my heart.

DLGAP3
Identifiers
Aliases	DLGAP3, DAP3, SAPAP3, discs large homolog associated protein 3, DLG associated protein 3, SPAPA3
External IDs	OMIM: 611413; MGI: 3039563; GeneCards: DLGAP3
Gene location (Human)
Chr.	Chromosome 1 (human)
End	34,929,650 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	127,130,815 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; cingulate gyrus; ; anterior cingulate cortex; ; nucleus accumbens; ; prefrontal cortex; ; putamen; ; Brodmann area 9; ; amygdala; ; caudate nucleus; ; right hemisphere of cerebellum;
	Top expressed in
	superior frontal gyrus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; hippocampus proper; ; prefrontal cortex; ; nucleus accumbens; ; cerebellar cortex; ; nucleus of stria terminalis; ; temporal lobe; ; neural layer of retina;
	More reference expression data
	n/a
Gene ontology
Molecular function	amyloid-beta binding; protein binding; protein domain specific binding;
Cellular component	cell junction; postsynaptic membrane; postsynaptic density; membrane; plasma membrane; synapse; neuromuscular junction; glutamatergic synapse; cholinergic synapse; postsynaptic specialization;
Biological process	signaling; modification of synaptic structure;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	58512
	242667
	ENSG00000116544
	ENSMUSG00000042388
	O95886
	Q6PFD5
	NM_001080418
	NM_001302081; NM_198618
	NP_001073887
	NP_001289010; NP_941020
	Wikidata
View/Edit Human	View/Edit Mouse

Disks large-associated protein 3 (DAP-3) also known as SAP90/PSD-95-associated protein 3 (SAPAP-3) is a protein that in humans is encoded by the DLGAP3 gene.

Clinical significance

Mutations in DLGAP3 have been associated with trichotillomania.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000116544 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042388 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Züchner S, Wendland JR, Ashley-Koch AE, Collins AL, Tran-Viet KN, Quinn K, et al. (January 2009). "Multiple rare SAPAP3 missense variants in trichotillomania and OCD". Molecular Psychiatry. 14 (1): 6–9. doi:10.1038/mp.2008.83. PMC 2803344. PMID 19096451.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000116544 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042388 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Züchner S, Wendland JR, Ashley-Koch AE, Collins AL, Tran-Viet KN, Quinn K, et al. (January 2009). "Multiple rare SAPAP3 missense variants in trichotillomania and OCD". Molecular Psychiatry. 14 (1): 6–9. doi:10.1038/mp.2008.83. PMC 2803344. PMID 19096451.

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