// Workers AI · dad joke modeWhat did DCTN4 say to DCTN3? You're one digit behind.

DCTN4
Identifiers
Aliases	DCTN4, DYN4, P62, dynactin subunit 4
External IDs	OMIM: 614758; MGI: 1914915; HomoloGene: 9430; GeneCards: DCTN4; OMA:DCTN4 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q33.1 Start 150,708,440 bp End 150,759,095 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 D3 Start 60,659,257 bp End 60,691,838 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in biceps brachii Skeletal muscle tissue of rectus abdominis Skeletal muscle tissue of biceps brachii retinal pigment epithelium tail of epididymis corpus epididymis lactiferous duct pars reticulata pars compacta caput epididymis Top expressed in genital tubercle cumulus cell pineal gland tail of embryo supraoptic nucleus ciliary body renal corpuscle aortic valve medullary collecting duct retinal pigment epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding protein N-terminus binding Cellular component cytoplasm cytosol centrosome cytoplasmic dynein complex cytoskeleton nucleus dynactin complex microtubule organizing center kinetochore spindle pole stress fiber focal adhesion cell cortex sarcomere Biological process endoplasmic reticulum to Golgi vesicle-mediated transport nuclear migration antigen processing and presentation of exogenous peptide antigen via MHC class II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51164 67665 Ensembl ENSG00000132912 ENSMUSG00000024603 UniProt Q9UJW0 Q8CBY8 RefSeq (mRNA) NM_001135643 NM_001135644 NM_016221 NM_026302 NM_001357462 RefSeq (protein) NP_001129115 NP_001129116 NP_057305 NP_080578 NP_001344391 Location (UCSC) Chr 5: 150.71 – 150.76 Mb Chr 18: 60.66 – 60.69 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Dynactin subunit 4 is a protein that in humans is encoded by the DCTN4 gene.

Further reading

• Karki S, Tokito MK, Holzbaur EL (February 2000). "A dynactin subunit with a highly conserved cysteine-rich motif interacts directly with Arp1". The Journal of Biological Chemistry. 275 (7): 4834–9. doi:10.1074/jbc.275.7.4834. PMID 10671518.
• Emond MJ, Louie T, Emerson J, Zhao W, Mathias RA, Knowles MR, Wright FA, Rieder MJ, Tabor HK, Nickerson DA, Barnes KC, Gibson RL, Bamshad MJ (July 2012). "Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis". Nature Genetics. 44 (8): 886–9. doi:10.1038/ng.2344. PMC 3702264. PMID 22772370.
• Ayalon G, Davis JQ, Scotland PB, Bennett V (December 2008). "An ankyrin-based mechanism for functional organization of dystrophin and dystroglycan". Cell. 135 (7): 1189–200. doi:10.1016/j.cell.2008.10.018. PMID 19109891. S2CID 17268857.
• Bingham JB, Schroer TA (February 1999). "Self-regulated polymerization of the actin-related protein Arp1". Current Biology. 9 (4): 223–6. Bibcode:1999CBio....9..223B. doi:10.1016/S0960-9822(99)80095-5. PMID 10074429. S2CID 208851.
• Lim CM, Cater MA, Mercer JF, La Fontaine S (May 2006). "Copper-dependent interaction of dynactin subunit p62 with the N terminus of ATP7B but not ATP7A". The Journal of Biological Chemistry. 281 (20): 14006–14. doi:10.1074/jbc.M512745200. hdl:10536/DRO/DU:30003771. PMID 16554302.
• Boultwood J, Fidler C, Strickson AJ, Watkins F, Kostrzewa M, Jaju RJ, Müller U, Wainscoat JS (May 2000). "Transcription mapping of the 5q- syndrome critical region: cloning of two novel genes and sequencing, expression, and mapping of a further six novel cDNAs". Genomics. 66 (1): 26–34. doi:10.1006/geno.2000.6193. PMID 10843801.