// Workers AI · dad joke modeWhat did cyclohexyl acetate say? "I'm cyclic about being great.

Cyclohexyl acetate
Names
	IUPAC name Cyclohexyl acetate
	Other names Acetoxycyclohexane; Acetic acid, cyclohexyl ester; Hexalin acetate; Cyclohexanol acetate; Cyclohexane acetate; Cyclohexanyl acetate;
Identifiers
CAS Number	622-45-7;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:31447;
ChemSpider	11647;
ECHA InfoCard	100.009.761
EC Number	210-736-6;
KEGG	C12297;
PubChem CID	12146;
UNII	UL0RS4H1UE;
UN number	2243
CompTox Dashboard (EPA)	DTXSID6052299;
	InChI InChI=1S/C8H14O2/c1-7(9)10-8-5-3-2-4-6-8/h8H,2-6H2,1H3 Key: YYLLIJHXUHJATK-UHFFFAOYSA-N;
	SMILES CC(=O)OC1CCCCC1;
Properties
Chemical formula	C8H14O2
Molar mass	142.198 g·mol−1
Appearance	Colorless liquid
Odor	Fruity, sweet, banana or apple
Density	0.966 g/cm3
Melting point	−77 °C (−107 °F; 196 K)
Boiling point	173 °C (343 °F; 446 K)
Solubility in water	Insoluble;; 1.56 g/l
Solubility	Miscible with diethyl ether.
Solubility in ethanol	580.47 g/l
Solubility in methanol	769.91 g/l
Solubility in isopropanol	596.92 g/l
Vapor pressure	14.6 hPa at 25 °C; 35 hPa at 50 °C; 60 hPa at 65 °C; ;
Refractive index (nD)	1.439
Hazards
	Occupational safety and health (OHS/OSH):
Main hazards	Highly flammable, eye and respiratory tract irritation
	GHS labelling:
Pictograms
Signal word	Warning
Hazard statements	H226, H315
Precautionary statements	P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, P501
Flash point	58 °C (136 °F; 331 K)
Autoignition; temperature	330 °C (626 °F; 603 K)
	Lethal dose or concentration (LD, LC):
LD50 (median dose)	6.73 g/kg (rat, oral); 10.1 g/kg (rabbit, dermal); ;
Related compounds
Related compounds	Hexyl acetate; Phenyl acetate;
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Cyclohexyl acetate is an organic compound with the chemical formula CH₃CO₂C₆H₁₁. It is a colorless liquid with a fruity, sweet, banana or apple odor. It is the cyclohexyl ester of acetic acid.

Synthesis

Cyclohexyl acetate can be synthesized by esterification reaction between acetic acid and cyclohexanol at elevated temperature with trace amounts of sulfuric acid as a catalyst^[1]^[6] or by reaction of cyclohexene with acetic acid.^[7]

Occurrence

Cyclohexyl acetate has been reported in Glycine max (soybean), Malus pumila (paradise apple), Garcinia dulcis, Mangifera indica (mango), Malus domestica (apple), Allium cepa (onion), Allium fistulosum (Welsh onion), Brassica (cabbage family) and even in Homo sapiens (human).^[1]

Uses

Cyclohexyl acetate is used as a solvent and in making rubber. It is a powerful solvent for nitrocellulose and other cellulose esters, many resins, gums. It is also used leather industry for improving adhesion of leather varnishes. In the food industry, it is used as a flavoring agent.^[1] Can be used as a paint solvent.^[4] Cyclohexyl acetate is used as a fragrance in cosmetics and cleaning agents.^[8]

Safety

Vapors of cyclohexyl acetate are much heavier than air and may be narcotic in high concentrations. Vapors are heavier than air and may travel to the source of ignition and flash back. Vapor may form explosive mixtures with air. The lower explosive limit (LEL) is 0.9 vol% (54 g/m³). It is skin, eye and respiratory tract irritant. May cause drowsiness, lowered consciousness and unconsciousness upon vapor inhalation or ingestion of large quantities, but it is safe when used as a flavoring agent. Cyclohexyl acetate emits acrid smoke and irritating fumes when heated to high temperatures. Containers of cyclohexyl acetate may explode when heated.^[1] Do not spill into drains because of risk of explosion.^[3]

References

1 2 3 4 5 6 7 8 9 10 11 12 13 14 PubChem. "Cyclohexyl acetate". pubchem.ncbi.nlm.nih.gov. Retrieved 21 March 2026.
1 2 3 4 5 scent.vn. "Cyclohexyl Acetate". scent.vn. Retrieved 21 March 2026.
1 2 Sigma-Aldrich. "Cyclohexyl acetate". www.sigmaaldrich.com. Retrieved 22 March 2026.
1 2 3 4 5 6 Chemical Book. "Cyclohexyl acetate". www.chemicalbook.com. Retrieved 22 March 2026.
↑ GESTIS substance database. "Cyclohexyl acetate". gestis.dguv.de. Retrieved 22 March 2026.
↑ Yadav, Ganapati D.; Mehta, Pranav H. (September 1, 1994). "Heterogeneous Catalysis in Esterification Reactions: Preparation of Phenethyl Acetate and Cyclohexyl Acetate by Using a Variety of Solid Acidic Catalysts". Industrial & Engineering Chemistry Research. 33 (9): 2198–2208. doi:10.1021/ie00033a025 – via ACS Publications.
↑ Hu, Yabo; Wang, Le; Lu, Jiawei; Ding, Lianghui; Zhang, Guowen; Zhang, Zhuxiu; Tang, Jihai; Cui, Mifen; Chen, Xian; Qiao, Xu (11 April 2023). "Novel Reactive Distillation Process for Cyclohexyl Acetate Production: Design, Optimization, and Control". ACS Omega. 8 (14): 13192–13201. doi:10.1021/acsomega.3c00469. ISSN 2470-1343. PMC 10099445. PMID 37065013.
↑ Bhatia, S. P.; Letizia, C. S.; Api, A. M. (December 1, 2008). "Fragrance material review on cyclohexyl acetate". Food and Chemical Toxicology. 46 (12, Supplement): S52–S55. doi:10.1016/j.fct.2008.09.033 – via ScienceDirect.

[pubchem-1] 1 2 3 4 5 6 7 8 9 10 11 12 13 14 PubChem. "Cyclohexyl acetate". pubchem.ncbi.nlm.nih.gov. Retrieved 21 March 2026.

[scent-2] 1 2 3 4 5 scent.vn. "Cyclohexyl Acetate". scent.vn. Retrieved 21 March 2026.

[sigmaaldrich-3] 1 2 Sigma-Aldrich. "Cyclohexyl acetate". www.sigmaaldrich.com. Retrieved 22 March 2026.

[chemicalbook-4] 1 2 3 4 5 6 Chemical Book. "Cyclohexyl acetate". www.chemicalbook.com. Retrieved 22 March 2026.

[gestis-5] GESTIS substance database. "Cyclohexyl acetate". gestis.dguv.de. Retrieved 22 March 2026.

[pubs-6] Yadav, Ganapati D.; Mehta, Pranav H. (September 1, 1994). "Heterogeneous Catalysis in Esterification Reactions: Preparation of Phenethyl Acetate and Cyclohexyl Acetate by Using a Variety of Solid Acidic Catalysts". Industrial & Engineering Chemistry Research. 33 (9): 2198–2208. doi:10.1021/ie00033a025 – via ACS Publications.

[pubs1-7] Hu, Yabo; Wang, Le; Lu, Jiawei; Ding, Lianghui; Zhang, Guowen; Zhang, Zhuxiu; Tang, Jihai; Cui, Mifen; Chen, Xian; Qiao, Xu (11 April 2023). "Novel Reactive Distillation Process for Cyclohexyl Acetate Production: Design, Optimization, and Control". ACS Omega. 8 (14): 13192–13201. doi:10.1021/acsomega.3c00469. ISSN 2470-1343. PMC 10099445. PMID 37065013.

[sciencedirect-8] Bhatia, S. P.; Letizia, C. S.; Api, A. M. (December 1, 2008). "Fragrance material review on cyclohexyl acetate". Food and Chemical Toxicology. 46 (12, Supplement): S52–S55. doi:10.1016/j.fct.2008.09.033 – via ScienceDirect.

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