// Workers AI · dad joke modeWhat did ADAP2 say to its date? You adapt well to me.

ADAP2
Identifiers
Aliases	ADAP2, CENTA2, HSA272195, cent-b, ArfGAP with dual PH domains 2
External IDs	OMIM: 608635; MGI: 2663075; GeneCards: ADAP2
Gene location (Human) Chr. Chromosome 17 (human) Band 17q11.2 Start 30,906,344 bp End 30,959,322 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 B5|11 47.56 cM Start 80,154,105 bp End 80,178,958 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte synovial membrane amniotic fluid granulocyte placenta spleen trabecular bone gingival epithelium blood synovial joint Top expressed in Rostral migratory stream right kidney stroma of bone marrow lumbar subsegment of spinal cord left lobe of liver human kidney jejunum blastocyst duodenum proximal tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function inositol 1,3,4,5 tetrakisphosphate binding protein-macromolecule adaptor activity phosphatidylinositol-4,5-bisphosphate binding protein binding phosphatidylinositol-3,4,5-trisphosphate binding metal ion binding GTPase activator activity phosphatidylinositol-3,4-bisphosphate binding phosphatidylinositol bisphosphate binding Cellular component cytoplasm plasma membrane mitochondrial envelope membrane Biological process development of the heart positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 55803 216991 Ensembl ENSG00000184060 ENSMUSG00000020709 UniProt Q9NPF8 Q8R2V5 RefSeq (mRNA) NM_001346712 NM_001346714 NM_001346716 NM_018404 NM_172133 RefSeq (protein) NP_001333641 NP_001333643 NP_001333645 NP_060874 NP_742145 Location (UCSC) Chr 17: 30.91 – 30.96 Mb Chr 11: 80.15 – 80.18 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Arf-GAP with dual PH domain-containing protein 2 is a protein that in humans is encoded by the ADAP2 gene.

External links

• Human ADAP2 genome location and ADAP2 gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Jenne DE, Tinschert S, Stegmann E, et al. (2000). "A common set of at least 11 functional genes is lost in the majority of NF1 patients with gross deletions". Genomics. 66 (1): 93–7. doi:10.1006/geno.2000.6179. PMID 10843809.
• Whitley P, Gibbard AM, Koumanov F, et al. (2003). "Identification of centaurin-alpha2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle". Eur. J. Cell Biol. 81 (4): 222–30. doi:10.1078/0171-9335-00242. PMID 12018390.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hanck T, Stricker R, Sedehizade F, Reiser G (2004). "Identification of gene structure and subcellular localization of human centaurin alpha 2, and p42IP4, a family of two highly homologous, Ins 1,3,4,5-P4-/PtdIns 3,4,5-P3-binding, adapter proteins". J. Neurochem. 88 (2): 326–36. doi:10.1046/j.1471-4159.2003.02143.x. PMID 14690521. S2CID 19363530.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Venturin M, Bentivegna A, Moroni R, et al. (2005). "Evidence by expression analysis of candidate genes for congenital heart defects in the NF1 microdeletion interval". Ann. Hum. Genet. 69 (Pt 5): 508–16. doi:10.1111/j.1529-8817.2005.00203.x. PMID 16138909. S2CID 45891228.
• Douglas J, Cilliers D, Coleman K, et al. (2007). "Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth". Nat. Genet. 39 (8): 963–5. doi:10.1038/ng2083. hdl:2381/22044. PMID 17632510. S2CID 35797973.