159

159 may refer to:

• 159 (number), the natural number following 158 and preceding 160
• AD 159, a year
• 159 BC, a year
• 159 (New Jersey bus), United States
• 159 (telephone number), a UK telephone number
• UFC 159, a mixed martial arts event held by the Ultimate Fighting Championship
• Alfa Romeo 159, a compact executive car
• Alfa Romeo 159, a Grand Prix racing car
• 159 series, an electric multiple unit rain type
• Lectionary 159, a Greek manuscript of the New Testament
• British Rail Class 159, a DMU train used in the UK