UNC5C

UNC5C
Identifiers
Aliases	UNC5C, UNC5H3, unc-5 netrin receptor C
External IDs	OMIM: 603610; MGI: 1095412; GeneCards: UNC5C
Gene location (Human) Chr. Chromosome 4 (human) Band 4q22.3 Start 95,162,504 bp End 95,549,206 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3 H1|3 65.57 cM Start 141,170,977 bp End 141,540,685 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum tibia internal globus pallidus pons inferior ganglion of vagus nerve subthalamic nucleus testicle right coronary artery C1 segment superior vestibular nucleus Top expressed in genital tubercle secondary oocyte supraoptic nucleus zygote otic vesicle ethmoid bone suprachiasmatic nucleus ascending aorta cerebellar vermis cribriform plate More reference expression data BioGPS More reference expression data
Gene ontology Molecular function netrin receptor activity netrin receptor activity involved in chemorepulsion protein binding protein kinase binding tubulin binding Cellular component integral component of membrane neuron projection cell junction plasma membrane synapse membrane axon dendrite growth cone soma lamellipodium filopodium cell surface cell projection Biological process positive regulation of apoptotic process netrin-activated signaling pathway multicellular organism development brain development regulation of cell migration signal transduction anterior/posterior axon guidance axon guidance apoptotic process negative chemotaxis chemorepulsion of axon dorsal root ganglion development Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 8633 22253 Ensembl ENSG00000182168 ENSMUSG00000059921 UniProt O95185 O08747 RefSeq (mRNA) NM_003728 NM_001293561 NM_009472 RefSeq (protein) NP_003719 NP_001280490 NP_033498 Location (UCSC) Chr 4: 95.16 – 95.55 Mb Chr 3: 141.17 – 141.54 Mb PubMed search
Wikidata
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Netrin receptor UNC5C is a protein that in humans is encoded by the UNC5C gene.

This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region.

Further reading

• Kennedy TE (2001). "Cellular mechanisms of netrin function: long-range and short-range actions". Biochem. Cell Biol. 78 (5): 569–75. doi:10.1139/bcb-78-5-569. PMID 11103947.
• Livesey FJ (2001). "Netrins and netrin receptors". Cell. Mol. Life Sci. 56 (1–2): 62–8. doi:10.1007/s000180050006. PMC 11146895. PMID 11213262. S2CID 33776808.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Thiebault K, Mazelin L, Pays L, et al. (2003). "The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4173–8. Bibcode:2003PNAS..100.4173T. doi:10.1073/pnas.0738063100. PMC 153067. PMID 12655055.
• Geisbrecht BV, Dowd KA, Barfield RW, et al. (2003). "Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin". J. Biol. Chem. 278 (35): 32561–8. doi:10.1074/jbc.M302943200. PMID 12810718.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kruger RP, Lee J, Li W, Guan KL (2005). "Mapping netrin receptor binding reveals domains of Unc5 regulating its tyrosine phosphorylation". J. Neurosci. 24 (48): 10826–34. doi:10.1523/JNEUROSCI.3715-04.2004. PMC 6730211. PMID 15574733.
• Llambi F, Lourenço FC, Gozuacik D, et al. (2005). "The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase". EMBO J. 24 (6): 1192–201. doi:10.1038/sj.emboj.7600584. PMC 556396. PMID 15729359.
• Bernet A, Mazelin L, Coissieux MM, et al. (2008). "Inactivation of the UNC5C Netrin-1 receptor is associated with tumor progression in colorectal malignancies". Gastroenterology. 133 (6): 1840–8. doi:10.1053/j.gastro.2007.08.009. PMC 2211510. PMID 17967459.