Talk:Pralidoxime
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[edit]The description of the mechanism is poorly written and therefore difficult to understand. It should be rewritten. Specifically, the first sentence contains excess clauses that obscure the meaning. Also, the explanation of 'aging' of the adduct is too vague, and warrants a more careful biochemical explanation; there is no such thing as a "permanent bond".
— Preceding unsigned comment added by 68.84.160.177 (talk) 16:07, 25 November 2012 (UTC)
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I agree with you. The mechanism of action section is extremely poor. I don't understand it at all, most probably because it makes no sense. I would gladly correct it but I don't know the mechanism of action of this substance so I can't. However I know enough about pharmacology to see it's currently flawed.
MOA of 2-PAM
[edit]for information on the MOA of 2-PAM, see the CDC's Agency for Toxic Substances and Disease Registry:
http://www.atsdr.cdc.gov/csem/cholinesterase/pam_medications.html
--74.179.96.106 (talk) 19:30, 26 September 2010 (UTC)
Charges
[edit]Would this not be dipolar in solution, with a -N-O- group (betaine or zwitterion)? I feel that this is important because it would make it much more nucleophilic. Zwitterions are also much more water soluble but have difficulty crossing lipid cell membranes. That's a real problem for a time-critical antidote, so it might be interesting to hear how it gets in (co-opting an active transport system)? Project Osprey (talk) 09:46, 7 June 2024 (UTC)