Talk:Dichloropane
Add topicLatest comment: 17 years ago by Meodipt in topic Prodrug?
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Prodrug?
[edit]Would the chloride links be what make dichloropane have a "slower onset" than cocaine thus needing to break down before taking effect (rather than some prodrug's increased lipid solubility a decreased lipid solubility) and thus making dichloropane a cocaine prodrug? Nagelfar (talk) 02:13, 18 October 2008 (UTC)
- No, the chloride groups on the aromatic ring are stable, indeed I doubt they even get removed by the body at all and most likely the only metabolic degradation of this compound is demethylation of the 2β-carbomethoxy group to carboxy (and perhaps N-demethylation also). The slower onset of this drug is due to slower passage across the blood-brain barrier which presumably stems from pharmacokinetic differences, in lipophilicity for instance, although I'm not sure the precise reason for the slower onset and longer duration (compared to say troparil for example) has been elucidated. Meodipt (talk) 01:33, 19 October 2008 (UTC)