SACM1L

SACM1L
Identifiers
Aliases	SACM1L, SAC1, SAC1 suppressor of actin mutations 1-like (yeast), SAC1 suppressor of actin mutations 1 like (yeast), SAC1 like phosphatidylinositide phosphatase
External IDs	OMIM: 606569; MGI: 1933169; HomoloGene: 6320; GeneCards: SACM1L; OMA:SACM1L - orthologs
Enzyme activity
Gene location (Human)
Chr.	Chromosome 3 (human)
End	45,745,409 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	123,421,665 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; Brodmann area 23; ; lateral nuclear group of thalamus; ; pars reticulata; ; endothelial cell; ; pars compacta; ; Epithelium of choroid plexus; ; visceral pleura; ; lower lobe of lung; ; renal medulla;
	Top expressed in
	deep cerebellar nuclei; ; medial vestibular nucleus; ; facial motor nucleus; ; substantia nigra; ; dorsal tegmental nucleus; ; pontine nuclei; ; lateral geniculate nucleus; ; mammillary body; ; Epithelium of choroid plexus; ; Paneth cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphatase activity; phosphoric ester hydrolase activity; phosphatidylinositol bisphosphate phosphatase activity; protein binding; hydrolase activity; phosphatidylinositol-4-phosphate phosphatase activity; phosphatidylinositol-3-phosphatase activity; phosphatidylinositol phosphate 4-phosphatase activity;
Cellular component	integral component of membrane; Golgi membrane; integral component of endoplasmic reticulum membrane; Golgi apparatus; AMPA glutamate receptor complex; endoplasmic reticulum membrane; endoplasmic reticulum; membrane;
Biological process	phosphatidylinositol biosynthetic process; phosphatidylinositol dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	22908
	83493
	ENSG00000211456
	ENSMUSG00000025240
	Q9NTJ5
	Q9EP69
	NM_014016; NM_001319072; NM_001319073; NM_001319071
	NM_030692; NM_001357485
	NP_001306001; NP_001306002; NP_054735; NP_001306000
	NP_109617; NP_001344414
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylinositide phosphatase SAC1 is an enzyme that in humans is encoded by the SACM1L gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000211456 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025240 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
↑ Kiss H, Kedra D, Kiss C, Kost-Alimova M, Yang Y, Klein G, Imreh S, Dumanski JP (May 2001). "The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3". Genomics. 73 (1): 10–9. doi:10.1006/geno.2000.6498. PMID 11352561.
↑ "Entrez Gene: SACM1L SAC1 suppressor of actin mutations 1-like (yeast)".

Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rohde HM, Cheong FY, Konrad G, et al. (2004). "The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex". J. Biol. Chem. 278 (52): 52689–99. doi:10.1074/jbc.M307983200. PMID 14527956.
Zhong R, Ye ZH (2003). "The SAC domain-containing protein gene family in Arabidopsis". Plant Physiol. 132 (2): 544–55. doi:10.1104/pp.103.021444. PMC 166996. PMID 12805586.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Nemoto Y, Kearns BG, Wenk MR, et al. (2000). "Functional characterization of a mammalian Sac1 and mutants exhibiting substrate-specific defects in phosphoinositide phosphatase activity". J. Biol. Chem. 275 (44): 34293–305. doi:10.1074/jbc.M003923200. PMID 10887188.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000211456 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025240 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10048485-5] Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.

[pmid11352561-6] Kiss H, Kedra D, Kiss C, Kost-Alimova M, Yang Y, Klein G, Imreh S, Dumanski JP (May 2001). "The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3". Genomics. 73 (1): 10–9. doi:10.1006/geno.2000.6498. PMID 11352561.

[entrez-7] "Entrez Gene: SACM1L SAC1 suppressor of actin mutations 1-like (yeast)".

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[3]

[4]

[5]

[6]

[7]

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SACM1L

References

Further reading