RNF168

RNF168
Identifiers
Aliases	RNF168, hring finger protein 168, RIDL
External IDs	OMIM: 612688; MGI: 1917488; HomoloGene: 87044; GeneCards: RNF168; OMA:RNF168 - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3L11, 4GB0
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.3.2.27 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 3 (human) Band 3q29 Start 196,468,783 bp End 196,503,768 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 B2 Start 32,096,277 bp End 32,120,252 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm tendon of biceps brachii pancreatic epithelial cell parietal pleura visceral pleura Achilles tendon epithelium of nasopharynx germinal epithelium gonad cardiac muscle tissue of right atrium Top expressed in zygote secondary oocyte genital tubercle primary oocyte Paneth cell hand otic vesicle tail of embryo substantia nigra facial motor nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function chromatin binding metal ion binding K63-linked polyubiquitin modification-dependent protein binding ubiquitin binding protein binding nucleosome binding transferase activity ubiquitin-protein transferase activity histone binding Cellular component site of double-strand break ubiquitin ligase complex nucleoplasm nucleus cytosol protein-containing complex Biological process response to ionizing radiation interstrand cross-link repair ubiquitin-dependent protein catabolic process histone H2A-K13 ubiquitination protein K63-linked ubiquitination histone H2A K63-linked ubiquitination negative regulation of transcription elongation from RNA polymerase II promoter cellular response to DNA damage stimulus protein ubiquitination isotype switching double-strand break repair via nonhomologous end joining DNA repair double-strand break repair histone H2A monoubiquitination histone H2A-K15 ubiquitination positive regulation of DNA repair chromatin organization histone H2A ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 165918 70238 Ensembl ENSG00000163961 ENSMUSG00000014074 UniProt Q8IYW5 Q80XJ2 RefSeq (mRNA) NM_152617 NM_027355 RefSeq (protein) NP_689830 NP_081631 Location (UCSC) Chr 3: 196.47 – 196.5 Mb Chr 16: 32.1 – 32.12 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Ring finger protein 168 is a protein that in humans is encoded by the RNF168 gene.

This gene encodes an E3 ubiquitin ligase protein that contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The protein is involved in double-strand breaks (DSB) repair. Mutations in this gene result in RIDDLE syndrome.

Further reading

• Kelliher J, Ghosal G, Leung JW (May 2022). "New answers to the old RIDDLE: RNF168 and the DNA damage response pathway". The FEBS Journal. 289 (9): 2467–2480. doi:10.1111/febs.15857. PMC 8486888. PMID 33797206.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.