Phenflutermine

Phenflutermine
Clinical data
Other names	Phenflutermin; 3-Trifluoromethyl-N-ethyl-α-methylamphetamine; 3-Trifluoromethyl-N-ethylphentermine; N-Ethyl-α,α-dimethyl-3-trifluoromethylphenethylamine; N-Et-α,α-Me-3-TFMPEA; Fenflutermine
ATC code	None;
Identifiers
	IUPAC name N-ethyl-2-methyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine;
Chemical and physical data
Formula	C13H18F3N
Molar mass	245.289 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCNC(C)(C)CC1=CC(C(F)(F)F)=CC=C1;
	InChI InChI=1S/C13H18F3N/c1-4-17-12(2,3)9-10-6-5-7-11(8-10)13(14,15)16/h5-8,17H,4,9H2,1-3H3; Key:DRSIPICEAYYBGT-UHFFFAOYSA-N;

Phenflutermine, also known as 3-trifluoromethyl-N-ethyl-α-methylamphetamine or as 3-trifluoromethyl-N-ethylphentermine, is a chemical compound of the phenethylamine, amphetamine, and phentermine families.^[1] It is the combined or hybrid derivative of the fenfluramine and phentermine, which were used together in the withdrawn combination anorectic fenfluramine/phentermine (Fen-Phen).^[1] The compound was first described in the scientific literature by Daniel Trachsel in his book on phenethylamines in 2013.^[1] It is not known to have been synthesized, tested, or otherwise described in the literature.^[1] However, both fenfluramine and phentermine are known to act as monoamine releasing agents and to have anorectic effects.^[2]^[3]

References

1 2 3 4 Trachsel D, Lehmann D, Enzensperger C (2013). Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science (in German) (1 ed.). Solothurn: Nachtschatten-Verlag. ISBN 978-3-03788-700-4. OCLC 858805226. Archived from the original on 21 August 2025.
↑ Rothman RB, Baumann MH (2000). "Neurochemical mechanisms of phentermine and fenfluramine: Therapeutic and adverse effects". Drug Development Research. 51 (2): 52–65. doi:10.1002/1098-2299(200010)51:2<52::AID-DDR2>3.0.CO;2-H. ISSN 0272-4391.
↑ Rothman RB, Baumann MH (2006). "Therapeutic potential of monoamine transporter substrates". Current Topics in Medicinal Chemistry. 6 (17): 1845–1859. doi:10.2174/156802606778249766. PMID 17017961.

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