PIK3IP1

PIK3IP1
Identifiers
Aliases	PIK3IP1, HGFL, hHGFL(S), phosphoinositide-3-kinase interacting protein 1, TrIP
External IDs	MGI: 1917016; GeneCards: PIK3IP1
Gene location (Human)
Chr.	Chromosome 22 (human)
End	31,292,534 bp
RNA expression pattern
	Top expressed in
	lymph node; ; olfactory zone of nasal mucosa; ; right lung; ; granulocyte; ; blood; ; gastric mucosa; ; spleen; ; tibial nerve; ; skin of leg; ; skin of abdomen;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	phosphatidylinositol 3-kinase catalytic subunit binding; protein binding;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of phosphatidylinositol 3-kinase activity;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	113791
	216505
	ENSG00000100100
	n/a
	Q96FE7
	Q7TMJ8
	NM_052880; NM_001135911
	NM_178149
	NP_001129383; NP_443112
	NP_835362
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphoinositide-3-kinase-interacting protein 1 (PIK3IP1) is an enzyme that in humans is encoded by the PIK3IP1 gene.^[4]^[5]

PIK3IP1 is a transmembrane protein that binds to PI3K, reducing signal to the PI3K/AKT/mTOR pathway.^[6] Through this mechanism, PIK3IP1 inhibits cell proliferation in tumor cells and is associated with cancer. PIK3IP1 is also associated with the inflammatory response and autoimmune diseases.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000100100 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
↑ "Entrez Gene: MGC17330 HGFL gene".
1 2 Jia Y, He P, Ma X, Lv K, Liu Y, Xu Y (August 2024). "PIK3IP1: structure, aberration, function, and regulation in diseases". European Journal of Pharmacology. 977 176753. doi:10.1016/j.ejphar.2024.176753. PMID 38897445.

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Collins JE, Goward ME, Cole CG, Smink LJ, Huckle EJ, Knowles S, et al. (January 2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22". Genome Research. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954. PMID 12529303.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–2824. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, et al. (2004). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology. 5 (10) R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, et al. (2005). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–126. doi:10.1093/dnares/12.2.117. PMID 16303743.
Zhu Z, He X, Johnson C, Stoops J, Eaker AE, Stoffer DS, et al. (June 2007). "PI3K is negatively regulated by PIK3IP1, a novel p110 interacting protein". Biochemical and Biophysical Research Communications. 358 (1): 66–72. doi:10.1016/j.bbrc.2007.04.096. PMC 1978172. PMID 17475214.

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