Oglufanide
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| Other names | IM-862; Oglufanide disodium; Thymogen |
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| Formula | C16H19N3O5 |
| Molar mass | 333.344 g·mol−1 |
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Oglufanide (Glu-Trp, Thymogen) is a dipeptide having the sequence L-Glu-L-Trp.[1][2] It is an immunomodulator and has been investigated for the treatment of Hepatitis C.[3][4][1] It was originally isolated from calf thymus gland extracts and has been used medicinally in Russia as a component of Thymalin, a mixture of thymus derived peptides and small proteins also containing other components such as thymosins and thymulin.[5][6][7] Synthetic versions of Glu-Trp containing unnatural D-amino acids or with gamma-peptide bond links also have different immunomodulatory effects such as the immunosuppressor thymodepressin (D-Glu-D-Trp).[8][9][2]
References
[edit]- 1 2 Kaushik NK, Kaushik N, Attri P, Kumar N, Kim CH, Verma AK, et al. (June 2013). "Biomedical importance of indoles". Molecules. 18 (6). Basel, Switzerland: 6620–6662. doi:10.3390/molecules18066620. PMC 6270133. PMID 23743888.
- 1 2 Deigin V, Linkova N, Vinogradova J, Vinogradov D, Polyakova V, Medvedev D, et al. (6 May 2024). "The First Reciprocal Activities of Chiral Peptide Pharmaceuticals: Thymogen and Thymodepressin, as Examples". International Journal of Molecular Sciences. 25 (9): 5042. doi:10.3390/ijms25095042. PMC 11084461. PMID 38732260.
- ↑ Nesterova IV (December 1999). "Modern Immunotherapy in Clinical Medicine: Present and Future". Russian Journal of Immunology. 4 (4): 322–326. PMID 12687147.
- ↑ Hamill P, Brown K, Jenssen H, Hancock RE (1 December 2008). "Novel anti-infectives: is host defence the answer?". Current Opinion in Biotechnology. 19 (6): 628–636. doi:10.1016/j.copbio.2008.10.006. PMID 19000763.
- ↑ Anisimov VN, Khavinson VK, Morozov VG (2000). "Immunomodulatory synthetic dipeptide L-Glu-L-Trp slows down aging and inhibits spontaneous carcinogenesis in rats". Biogerontology. 1 (1): 55–59. doi:10.1023/a:1010042008969. PMID 11707921.
- ↑ Malinin VV, Durnova AO, Polyakova VO, Kvetnoi IM (May 2015). "Dipeptides Increase Functional Activity of Human Skin Fibroblasts". Bulletin of Experimental Biology and Medicine. 159 (1): 164–167. doi:10.1007/s10517-015-2914-9. PMID 26033609.
- ↑ Avolio F, Martinotti S, Khavinson VK, Esposito JE, Giambuzzi G, Marino A, et al. (25 March 2022). "Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line". International Journal of Molecular Sciences. 23 (7): 3607. doi:10.3390/ijms23073607. PMC 8999041. PMID 35408963.
- ↑ Semina OV, Semenets TN, Zamulaeva IA, Selivanova EI, Malyutina YV, Saenko AS, et al. (February 2006). "Effects of structural and "mixed" isomers of Glu-Trp dipeptide on normal hemopoietic stem cells". Bulletin of Experimental Biology and Medicine. 141 (2): 250–253. doi:10.1007/s10517-006-0141-0. PMID 16984110.
- ↑ Deigin VI, Semenets TN, Zamulaeva IA, Maliutina YV, Selivanova EI, Saenko AS, et al. (March 2007). "The effects of the EW dipeptide optical and chemical isomers on the CFU-S population in intact and irradiated mice". International Immunopharmacology. 7 (3): 375–382. doi:10.1016/j.intimp.2006.11.010. PMID 17276896.