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Normalized chromosome value

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From Wikipedia, the free encyclopedia

Normalized chromosome value (NCV) is a mathematical calculation for comparing each chromosome under tested in cell free DNA (cfDNA) for detecting genetic disorder of the fetus. NCV calculation removes variation within and between sequencing runs to optimize test precision.[1][2]

References

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  1. ↑ "Clinical Data". Verinata. 2012-01-11. Retrieved 2013-08-19.
  2. ↑ Sehnert AJ, et al. (Jul 2011). "Optimal detection of fetal chromosomal abnormalities by massively parallel DNA sequencing of cell-free fetal DNA from maternal blood". Clin. Chem. 57 (7): 1042–9. doi:10.1373/clinchem.2011.165910. PMID 21519036.


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