NRD1

NRDC
Identifiers
Aliases	NRDC, hNRD1, hNRD2, NRD1, nardilysin convertase, nardilysin
External IDs	OMIM: 602651; MGI: 1201386; HomoloGene: 68260; GeneCards: NRDC; OMA:NRDC - orthologs
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 3.4.24.61 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 1 (human) Band 1p32.3 Start 51,789,191 bp End 51,878,805 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 C7 Start 108,857,852 bp End 108,918,974 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in glutes right testis left testis muscle of thigh triceps brachii muscle gastrocnemius muscle anterior pituitary sperm Skeletal muscle tissue of biceps brachii thoracic diaphragm Top expressed in seminiferous tubule tail of embryo genital tubercle granulocyte spermatid plantaris muscle neural layer of retina muscle of thigh extensor digitorum longus muscle lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity protein binding catalytic activity metallopeptidase activity hydrolase activity metal ion binding epidermal growth factor binding metalloendopeptidase activity Cellular component cell surface cytosol mitochondrion Biological process positive regulation of membrane protein ectodomain proteolysis cell population proliferation neuromuscular junction development cell migration regulation of endopeptidase activity proteolysis negative regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4898 230598 Ensembl ENSG00000078618 ENSMUSG00000053510 UniProt O43847 Q8BHG1 RefSeq (mRNA) NM_001101662 NM_001242361 NM_002525 NM_146150 NM_001346554 NM_001347169 RefSeq (protein) NP_001095132 NP_001229290 NP_002516 NP_001333483 NP_001334098 NP_666262 Location (UCSC) Chr 1: 51.79 – 51.88 Mb Chr 4: 108.86 – 108.92 Mb PubMed search
Wikidata
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Nardilysin is an enzyme that in humans is encoded by the gene NRDC (formally NRD1). Nardilysin is a type of protease, which means it functions to cut the bonds between certain amino acids. More specifically, it’s an endopeptidase that cleaves bonds at the N-terminus of arginine residues connected to other basic amino acids. This activity also explains its alternative name, N-arginine dibasic convertase, hence its standard name.

Interactions

Nardilysin has been shown to interact with Heparin-binding EGF-like growth factor.

See also

• Nardilysin — the enzyme type

Further reading

• Seidah NG, Prat A (2003). "Precursor convertases in the secretory pathway, cytosol and extracellular milieu". Essays Biochem. 38: 79–94. doi:10.1042/bse0380079. PMID 12463163.
• Hospital V, Prat A (2005). "Nardilysin, a basic residues specific metallopeptidase that mediates cell migration and proliferation". Protein Pept. Lett. 11 (5): 501–8. doi:10.2174/0929866043406508. PMID 15544571.
• Winter AG, Pierotti AR (2001). "Gene expression of the dibasic-pair cleaving enzyme NRD convertase (N-arginine dibasic convertase) is differentially regulated in the GH3 pituitary and Mat-Lu prostate cell lines". Biochem. J. 351 (3): 755–64. doi:10.1042/0264-6021:3510755. PMC 1221416. PMID 11042131.
• Nishi E, Prat A, Hospital V, et al. (2001). "N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration". EMBO J. 20 (13): 3342–50. doi:10.1093/emboj/20.13.3342. PMC 125525. PMID 11432822.
• Ma Z, Csuhai E, Chow KM, Hersh LB (2001). "Expression of the acidic stretch of nardilysin as a functional binding domain". Biochemistry. 40 (31): 9447–52. doi:10.1021/bi010538x. PMID 11478915.
• Hospital V, Nishi E, Klagsbrun M, et al. (2003). "The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF)". Biochem. J. 367 (Pt 1): 229–38. doi:10.1042/BJ20020822. PMC 1222870. PMID 12095415.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chow KM, Oakley O, Goodman J, et al. (2003). "Nardilysin cleaves peptides at monobasic sites". Biochemistry. 42 (7): 2239–44. doi:10.1021/bi027178d. PMID 12590613.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Nishi E, Hiraoka Y, Yoshida K, et al. (2006). "Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor-alpha-converting enzyme". J. Biol. Chem. 281 (41): 31164–72. doi:10.1074/jbc.M601316200. PMID 16923819.
• Bernstein HG, Stricker R, Dobrowolny H, et al. (2007). "Histochemical evidence for wide expression of the metalloendopeptidase nardilysin in human brain neurons". Neuroscience. 146 (4): 1513–23. doi:10.1016/j.neuroscience.2007.02.057. PMID 17442499. S2CID 8060302.