Kupe virus
| Kupe virus | |
|---|---|
Virus classification  | |
| (unranked): | Virus |
| Realm: | Riboviria |
| Kingdom: | Orthornavirae |
| Phylum: | Negarnaviricota |
| Class: | Bunyaviricetes |
| Order: | Hareavirales |
| Family: | Nairoviridae |
| Genus: | Orthonairovirus |
| Species: | Orthonairovirus amblyommae |
| Synonyms[1] | |
| |
Kupe virus is a species of virus in the genus Orthonairovirus.[2]
History
[edit]The virus was isolated from pooled ticks (Amblyomma gemma and Rhipicephalus pulchellus) collected from cattle hides in Nairobi, Kenya, in October 1999.[3] The word 'Kupe' is Kiswahili for tick.
Genome
[edit]The genome is composed a single strand of negative sense RNA in three parts - small (S), medium (M0 and large(L).
The L segment RNA is 12,330 nucleotides (nt) in length and encodes one open reading frame (ORF) of 4,050 amino acids. There is a non coding regions: the 5′ region of 40 nt and the 3′ region of 137 nt. This open reading frame encodes several modules including a RNA-dependent RNA polymerase. It is probably post translationally cleaved into several proteins but this has yet to be shown.
The M segment RNA is 4,818 nucleotides in length and contains one open reading frame flanked by 5′ and 3′ non coding regions of 47 and 121 nucleotides respectively. The ORF encodes a protein of 1549 amino acids with 8 potential sites for N-linked glycosylation. It contains a unique potential N-gly site in the Gn and Gc glycoprotein regions at amino acids 612 and 1514 respectively.
The S segment has 1,694 nt and encodes an ORF of 483 amino acids. The 5′ and 3′ noncoding regions are 49 nt and 193 nt in length respectively.
References
[edit]- ↑ "History of the taxon: Species: Orthonairovirus amblyommae (2024 Release, MSL #40)". Retrieved 18 March 2025.
- ↑ "Virus Taxonomy: 2024 Release". International Committee on Taxonomy of Viruses. Retrieved 18 March 2025.
- ↑ Sang R, Onyango C, Gachoya J, Mabinda E, Konongoi S, Ofula V, Dunster L, Okoth F, Coldren R, Tesh R, da Rossa AT, Finkbeiner S, Wang D, Crabtree M, Miller B (2006) Tickborne arbovirus surveillance in market livestock, Nairobi, Kenya. Emerg Infect Dis. 2006 Jul;12(7):1074-1080