HECW1

HECW1
Identifiers
Aliases	HECW1, NEDL1, HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
External IDs	OMIM: 610384; MGI: 2444115; HomoloGene: 9004; GeneCards: HECW1; OMA:HECW1 - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3L4H
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.3.2.26 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 7 (human) Band 7p14.1-p13 Start 43,112,629 bp End 43,566,001 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13 A1|13 5.29 cM Start 14,401,023 bp End 14,697,813 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 middle temporal gyrus endothelial cell primary visual cortex testicle ganglionic eminence prefrontal cortex dorsolateral prefrontal cortex superior frontal gyrus pons Top expressed in medial dorsal nucleus facial motor nucleus primary motor cortex anterior horn of spinal cord central gray substance of midbrain medial geniculate nucleus medial vestibular nucleus prefrontal cortex trigeminal ganglion lateral geniculate nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity ubiquitin-protein transferase activity ubiquitin protein ligase activity Cellular component cytosol cytoplasm Biological process negative regulation of canonical Wnt signaling pathway protein ubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process protein polyubiquitination ubiquitin-dependent protein catabolic process positive regulation of protein catabolic process regulation of dendrite morphogenesis negative regulation of sodium ion transmembrane transporter activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23072 94253 Ensembl ENSG00000002746 ENSMUSG00000021301 UniProt Q76N89 Q8K4P8 RefSeq (mRNA) NM_001287059 NM_015052 NM_001081348 NM_153130 NM_178809 RefSeq (protein) NP_001273988 NP_055867 NP_001074817 Location (UCSC) Chr 7: 43.11 – 43.57 Mb Chr 13: 14.4 – 14.7 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 is a protein that in humans is encoded by the HECW1 gene. In human it has 1606 amino acids (179.5 kDa) and isoelectric point of 5.18.

Further reading

• Miyazaki K, Fujita T, Ozaki T, Kato C, Kurose Y, Sakamoto M, Kato S, Goto T, Itoyama Y, Aoki M, Nakagawara A (March 2004). "NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1". The Journal of Biological Chemistry. 279 (12): 11327–35. doi:10.1074/jbc.M312389200. PMID 14684739.
• Chansard M, Wang J, Tran HC, Neumayer G, Shim SY, Park YU, Belzil C, Le HT, Park SK, Nguyen MD (January 2011). "The cytoskeletal protein Ndel1 regulates dynamin 2 GTPase activity". PLOS ONE. 6 (1) e14583. Bibcode:2011PLoSO...614583C. doi:10.1371/journal.pone.0014583. PMC 3026782. PMID 21283621.
• Sherva R, Tripodis Y, Bennett DA, Chibnik LB, Crane PK, de Jager PL, Farrer LA, Saykin AJ, Shulman JM, Naj A, Green RC (January 2014). "Genome-wide association study of the rate of cognitive decline in Alzheimer's disease". Alzheimer's & Dementia. 10 (1): 45–52. doi:10.1016/j.jalz.2013.01.008. PMC 3760995. PMID 23535033.
• Li Y, Ozaki T, Kikuchi H, Yamamoto H, Ohira M, Nakagawara A (June 2008). "A novel HECT-type E3 ubiquitin protein ligase NEDL1 enhances the p53-mediated apoptotic cell death in its catalytic activity-independent manner". Oncogene. 27 (26): 3700–9. doi:10.1038/sj.onc.1211032. PMID 18223681.
• Harvey KF, Dinudom A, Cook DI, Kumar S (March 2001). "The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel". The Journal of Biological Chemistry. 276 (11): 8597–601. doi:10.1074/jbc.C000906200. PMID 11244092.
• Zhang L, Haraguchi S, Koda T, Hashimoto K, Nakagawara A (2011). "Muscle atrophy and motor neuron degeneration in human NEDL1 transgenic mice". Journal of Biomedicine & Biotechnology. 2011: 1–7. doi:10.1155/2011/831092. PMC 2952905. PMID 20976258.
• Cui Y, He S, Xing C, Lu K, Wang J, Xing G, Meng A, Jia S, He F, Zhang L (May 2011). "SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1". The EMBO Journal. 30 (13): 2675–89. doi:10.1038/emboj.2011.155. PMC 3155294. PMID 21572392.
• Shinada K, Tsukiyama T, Sho T, Okumura F, Asaka M, Hatakeyama S (January 2011). "RNF43 interacts with NEDL1 and regulates p53-mediated transcription". Biochemical and Biophysical Research Communications. 404 (1): 143–7. doi:10.1016/j.bbrc.2010.11.082. hdl:2115/44929. PMID 21108931. S2CID 8665279.
• Levine DM, Ek WE, Zhang R, Liu X, Onstad L, Sather C, Lao-Sirieix P, Gammon MD, Corley DA, Shaheen NJ, Bird NC, Hardie LJ, Murray LJ, Reid BJ, Chow WH, Risch HA, Nyrén O, Ye W, Liu G, Romero Y, Bernstein L, Wu AH, Casson AG, Chanock SJ, Harrington P, Caldas I, Debiram-Beecham I, Caldas C, Hayward NK, Pharoah PD, Fitzgerald RC, Macgregor S, Whiteman DC, Vaughan TL (December 2013). "A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus". Nature Genetics. 45 (12): 1487–93. doi:10.1038/ng.2796. PMC 3840115. PMID 24121790.