Fluetonitazepyne

Fluetonitazepyne
Identifiers
	IUPAC name 2-[[4-(2-fluoroethoxy)phenyl]methyl]-5-nitro-1-(2-pyrrolidin-1-ylethyl)benzimidazole;
PubChem CID	172871918;
Chemical and physical data
Formula	C22H25FN4O3
Molar mass	412.465 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CCN(C1)CCN2C3=C(C=C(C=C3)[N+](=O)[O-])N=C2CC4=CC=C(C=C4)OCCF;
	InChI InChI=1S/C22H25FN4O3/c23-9-14-30-19-6-3-17(4-7-19)15-22-24-20-16-18(27(28)29)5-8-21(20)26(22)13-12-25-10-1-2-11-25/h3-8,16H,1-2,9-15H2; Key:TYLHUWCBBIQCEH-UHFFFAOYSA-N;

Fluetonitazepyne (F-etonitazepyne, 2-fluoroetonitazepyne) is a benzimidazole derivative which is an opioid designer drug.^[1] It was first identified in Italy in July 2024,^[2] and subsequently isolated in Finland in early 2025 from the body fluids of five people who had died from opioid overdose.^[3] It has also been detected in Germany. ^[4]

References

↑ Kozell LB, Eshleman AJ, Wolfrum KM, Swanson TL, Schutzer KA, Schutzer WE, et al. (15 September 2025). "Pharmacology of newly identified nitazene variants reveals structural determinants of affinity, potency, selectivity for mu opioid receptors". Neuropharmacology. 276 110512. doi:10.1016/j.neuropharm.2025.110512. PMC 12147671. PMID 40374158.
↑ "Fluetonitazene" (PDF). EU Early Warning System Formal Notification. European Union Drugs Agency (EUDA). 14 May 2024.
↑ Kriikku P, Pelander A, Jylhä A, Ojanperä I (2025). "Post-Mortem Identification and Toxicological Findings of Fluetonitazepyne and Isotonitazepyne". Drug Testing and Analysis. 17 (11) dta.3928. doi:10.1002/dta.3928. PMC 12580158. PMID 40879310.
↑ Picht F, Cepus V, Hohlfeld R, Klingbeil J, Weber M (April 2026). "Identification and Characterization of the Designer Opioid N-Pyrrolidino Fluetonitazene in Nasal Spray". Drug Testing and Analysis dta.70074. doi:10.1002/dta.70074. PMID 41983957.

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[1] Kozell LB, Eshleman AJ, Wolfrum KM, Swanson TL, Schutzer KA, Schutzer WE, et al. (15 September 2025). "Pharmacology of newly identified nitazene variants reveals structural determinants of affinity, potency, selectivity for mu opioid receptors". Neuropharmacology. 276 110512. doi:10.1016/j.neuropharm.2025.110512. PMC 12147671. PMID 40374158.

[2] "Fluetonitazene" (PDF). EU Early Warning System Formal Notification. European Union Drugs Agency (EUDA). 14 May 2024.

[3] Kriikku P, Pelander A, Jylhä A, Ojanperä I (2025). "Post-Mortem Identification and Toxicological Findings of Fluetonitazepyne and Isotonitazepyne". Drug Testing and Analysis. 17 (11) dta.3928. doi:10.1002/dta.3928. PMC 12580158. PMID 40879310.

[4] Picht F, Cepus V, Hohlfeld R, Klingbeil J, Weber M (April 2026). "Identification and Characterization of the Designer Opioid N-Pyrrolidino Fluetonitazene in Nasal Spray". Drug Testing and Analysis dta.70074. doi:10.1002/dta.70074. PMID 41983957.

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Fluetonitazepyne

See also

References