DCAF7

DCAF7
Identifiers
Aliases	DCAF7, AN11, HAN11, SWAN-1, WDR68, DDB1 and CUL4 associated factor 7
External IDs	OMIM: 605973; MGI: 1919083; GeneCards: DCAF7
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 E1 Start 105,927,698 bp End 105,950,150 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence oocyte secondary oocyte renal medulla cardia trabecular bone lower lobe of lung ventral tegmental area inferior ganglion of vagus nerve subthalamic nucleus Top expressed in superior cervical ganglion otolith organ utricle hand Paneth cell subiculum trigeminal ganglion anterior amygdaloid area paraventricular nucleus of hypothalamus arcuate nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component nuclear matrix Cul4-RING E3 ubiquitin ligase complex nucleus cytoplasm cytosol nuclear body nucleoplasm protein-containing complex Biological process multicellular organism development post-translational protein modification protein ubiquitination Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry Species Human Mouse Entrez 10238 71833 Ensembl n/a ENSMUSG00000049354 UniProt P61962 P61963 RefSeq (mRNA) NM_001003725 NM_005828 NM_027946 RefSeq (protein) NP_005819 NP_082222 Location (UCSC) n/a Chr 11: 105.93 – 105.95 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

DDB1- and CUL4-associated factor 7 is a protein that in humans is encoded by the DCAF7 gene. This protein may function as a substrate receptor for the CUL4-DDB1 complex, which functions as an E3 ubiquitin ligase.

Interactions

DCAF7 has been shown to interact with DYRK1A.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Skurat AV, Dietrich AD (2004). "Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases". J. Biol. Chem. 279 (4): 2490–8. doi:10.1074/jbc.M301769200. PMID 14593110.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Morita K, Lo Celso C, Spencer-Dene B, Zouboulis CC, Watt FM (2006). "HAN11 binds mDia1 and controls GLI1 transcriptional activity". J. Dermatol. Sci. 44 (1): 11–20. doi:10.1016/j.jdermsci.2006.06.001. PMID 16887337.
• Nissen RM, Amsterdam A, Hopkins N (2006). "A zebrafish screen for craniofacial mutants identifies wdr68 as a highly conserved gene required for endothelin-1 expression". BMC Dev. Biol. 6 (28): 28. doi:10.1186/1471-213X-6-28. PMC 1523201. PMID 16759393.
• Mazmanian G, Kovshilovsky M, Yen D, Mohanty A, Mohanty S, Nee A, Nissen RM (2010). "The zebrafish dyrk1b gene is important for endoderm formation". Genesis. 48 (1): 20–30. doi:10.1002/dvg.20578. PMC 2806492. PMID 20014342.
• Ritterhoff S, Farah CM, Grabitzki J, Lochnit G, Skurat AV, Schmitz ML (2010). "The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions". EMBO J. 29 (22): 3750–61. doi:10.1038/emboj.2010.251. PMC 2989105. PMID 20940704.

External links

• DCAF7 human gene location in the UCSC Genome Browser.
• DCAF7 human gene details in the UCSC Genome Browser.