CCL15

CCL15
Identifiers
Aliases	CCL15, HCC-2, HMRP-2B, LKN-1, LKN1, MIP-1 delta, MIP-1D, MIP-5, MRP-2B, NCC-3, NCC3, SCYA15, SCYL3, SY15, C-C motif chemokine ligand 15
External IDs	OMIM: 601393; GeneCards: CCL15
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2HCC
Gene location (Human)
Chr.	Chromosome 17 (human)
End	36,001,553 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; rectum; ; duodenum; ; right lobe of liver; ; olfactory zone of nasal mucosa; ; gallbladder; ; right uterine tube; ; right lung; ; human kidney; ; appendix;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; heparin binding; CCR chemokine receptor binding; chemoattractant activity; signaling receptor binding; chemokine activity;
Cellular component	extracellular region; extracellular space;
Biological process	G protein-coupled receptor signaling pathway; monocyte chemotaxis; chemokine-mediated signaling pathway; cell-cell signaling; cellular response to tumor necrosis factor; cellular calcium ion homeostasis; neutrophil chemotaxis; chemotaxis; positive regulation of GTPase activity; cellular response to interleukin-1; immune response; positive regulation of ERK1 and ERK2 cascade; cellular response to interferon-gamma; cell chemotaxis; lymphocyte chemotaxis; inflammatory response; signal transduction; positive chemotaxis; regulation of signaling receptor activity; eosinophil chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	6359
	n/a
	ENSG00000275718; ENSG00000275528
	n/a
	Q16663
	n/a
	NM_032965; NM_004167; NM_032964
	n/a
	NP_116741
	n/a
	Wikidata
View/Edit Human

Chemokine (C-C motif) ligand 15 (CCL15) is a small cytokine belonging to the CC chemokine family that is also known as leukotactin-1, MIP5 and HCC-2. CCL15 is expressed in liver, small intestine, colon, and in certain leukocytes and macrophages of the lung.^[3] It is chemotactic for neutrophils, monocytes, and lymphocytes and elicits its effects by binding to cell surface chemokine receptors like CCR1 and CCR3.^[4]^[5] The human CCL15 gene spans four exons and is located in a head-to-tail orientation on chromosome 17 with the gene of another CC chemokine known as CCL14.^[6]

References

1 2 3 ENSG00000275528 GRCh38: Ensembl release 89: ENSG00000275718, ENSG00000275528 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Pardigol et al. HCC-2, a human chemokine: gene structure, expression pattern, and biological activity. Proc. Natl. Acad. Sci. 95: 6308-6313, 1998.
↑ Youn et al. Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3. J. Immun. 159: 5201-5205, 1997.
↑ Coulin et al. Characterization of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines. Europ. J. Biochem. 248: 507-515, 1997.
↑ Naruse et al. A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics 34: 236-240, 1996.

External links

CCL15 GeneCard

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 ENSG00000275528 GRCh38: Ensembl release 89: ENSG00000275718, ENSG00000275528 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] Pardigol et al. HCC-2, a human chemokine: gene structure, expression pattern, and biological activity. Proc. Natl. Acad. Sci. 95: 6308-6313, 1998.

[4] Youn et al. Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3. J. Immun. 159: 5201-5205, 1997.

[5] Coulin et al. Characterization of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines. Europ. J. Biochem. 248: 507-515, 1997.

[6] Naruse et al. A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics 34: 236-240, 1996.

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References

External links