Betamipron

Betamipron
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	J01DH55 (WHO) (with panipenem);
Identifiers
	IUPAC name 3-(benzoylamino)propanoic acid;
CAS Number	3440-28-6 ;
PubChem CID	71651;
ChemSpider	64711 ;
UNII	3W0M245736;
ChEMBL	ChEMBL1231530 ;
CompTox Dashboard (EPA)	DTXSID0045626 ;
Chemical and physical data
Formula	C10H11NO3
Molar mass	193.202 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	120 °C (248 °F)
	SMILES O=C(NCCC(=O)O)c1ccccc1;
	InChI InChI=1S/C10H11NO3/c12-9(13)6-7-11-10(14)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,11,14)(H,12,13) ; Key:CWXYHOHYCJXYFQ-UHFFFAOYSA-N ;
	(what is this?) (verify)

Betamipron (INN) or N-benzoyl-β-alanine is a chemical adjunct which is used together with panipenem^[1] in the formulation sold as Carbenin to inhibit panipenem uptake into the renal tubule and prevent nephrotoxicity.^[2] Alone it has no antibacterial function.^[3]

References

↑ Finch RG (2003). Antibiotic and chemotherapy: anti-infective agents and their use in therapy. Elsevier Health Sciences. pp. 269–. ISBN 978-0-443-07129-4. Retrieved 8 August 2011.
↑ Goa KL, Noble S (2003). "Panipenem/betamipron". Drugs. 63 (9): 913–25, discussion 926. doi:10.2165/00003495-200363090-00005. PMID 12678575. S2CID 263994230.
↑ Ohashi N, Uematsu T, Nagashima S, Kanamaru M, Tajima N, Togawa A, et al. (February 2005). "Pharmacokinetics of panipenem/betamipron in patients with end-stage renal disease". Journal of Infection and Chemotherapy. 11 (1): 24–31. doi:10.1007/s10156-004-0359-6. PMID 15729484.

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[Finch2003-1] Finch RG (2003). Antibiotic and chemotherapy: anti-infective agents and their use in therapy. Elsevier Health Sciences. pp. 269–. ISBN 978-0-443-07129-4. Retrieved 8 August 2011.

[2] Goa KL, Noble S (2003). "Panipenem/betamipron". Drugs. 63 (9): 913–25, discussion 926. doi:10.2165/00003495-200363090-00005. PMID 12678575. S2CID 263994230.

[3] Ohashi N, Uematsu T, Nagashima S, Kanamaru M, Tajima N, Togawa A, et al. (February 2005). "Pharmacokinetics of panipenem/betamipron in patients with end-stage renal disease". Journal of Infection and Chemotherapy. 11 (1): 24–31. doi:10.1007/s10156-004-0359-6. PMID 15729484.

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Betamipron

See also

References