ARMCX5

ARMCX5
Identifiers
Aliases	ARMCX5, GASP5, armadillo repeat containing, X-linked 5, armadillo repeat containing X-linked 5
External IDs	MGI: 2148026; GeneCards: ARMCX5
Gene location (Human)
Chr.	X chromosome (human)
End	102,604,159 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	134,648,071 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; gonad; ; testicle; ; hair follicle; ; epithelium of nasopharynx; ; corpus epididymis; ; body of pancreas; ; rectum; ; cartilage tissue; ; mucosa of paranasal sinus;
	Top expressed in
	zygote; ; secondary oocyte; ; primary oocyte; ; ovary; ; hippocampus proper; ; granulocyte; ; superior frontal gyrus; ; hypothalamus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	n/a
Orthologs
Databases	NCBI: entry; OMA: entry
	64860
	494468
	ENSG00000125962
	ENSMUSG00000072969
	Q6P1M9
	Q3UZB0
NM_022838; NM_001168478; NM_001168479; NM_001168480; NM_001168482;
	NM_001168485
	NM_001009575
NP_001161950; NP_001161951; NP_001161952; NP_001161954; NP_001161957;
	NP_073749
	NP_001009575
	Wikidata
View/Edit Human	View/Edit Mouse

ARMCX5 is an armadillo repeat–containing protein that is encoded by the X-linked ARMCX5 gene. It is conserved only in Eutheria,^[5] a specific group of placental mammals, but no further back in evolutionary time. ARMCX5 contains 3 ARM-like repeats, DUF364, and ARM-type fold.^[6]

Features

Accession Number	NC_0002.10
Aliases	FLJ12969, FLJ13382, and RP4-769N13.3
Chromosomal location	Xq22.1-q22.3
Gene size	4991 base pairs
mRNA size	2924 base pairs
Protein size	588 amino acids

^[7]

Splice Variants

ARMCX5 has 6 splice variants.

Splice isoform/transcript variant	mRNA sequence length	Accession number
1	2924	NM_001168479.1
2	2695	NM_022838.3
3	2808	NM_001168478.1
4	2918	NM_001168480.1
5	2805	NM_001168485.1
6	2707	NM_001168482.1

^[7]

ORTHOLOGS

ARMCX5 has ten orthologs.

Ortholog genus name	Common name	Accession number	Sequence length	Sequence identity	Sequence similarity
Pongo abelli	Orangatuan	XP_002831961.1	547	97.1%	99%
Macaca mulata	Rhesus monkey	EHH30927.1	558	95.3%	97%
Macaca fascicularis	Crab eating macaque	EHH61076.1	558	95%	97%
Callithrix Jacchus	Common marmoset	XP_002763850.1	568	89.4%	93%
Equus caballus	Horse	NC009175.2	609	80%	85%
Canis lupus familiaris	dog	XP_538116.2	608	79%	85%
Sus scrofa	Common pig	XP_003135327.2	732	78%	85%
Oryctolagus cuniculus	Common rabbit	XP_00272091.1	547	76.8%	85%
Rattus norvegicus	Common rat	XP_001499348.2	567	61.1%	76%
Mus musculus	Mouse	NP_001009575.2	606	57%	71%

^[8]

Paralogs

ARMCX5 has 8 paralogs listed by genecards: GPRASP2, ARMCX1, BHLHB9, ARMCX2, GPRASP1, ARMCX6, ARMCX10, and ARMCX3.^[6]

Function

Proteins containing this ARMCX5 domain interact with numerous other proteins. Through these interactions, they are involved in a wide variety of processes including carcinogenesis, control of cellular ageing and survival, regulation f circadian rhythm and lysosomal sorting of G-protein coupled receptors.^[6]

Because DUF364 contains a PLP-dependent transferase-like fold, the genomic context suggests that it may have a role in anaerobic vitamin B12 biosynthesis.^[9]

Expression

ARMCX5 is a highly ubiquitously expressed gene that has shown expression in many tissues.

Body Site	Transcripts per million	Gene EST/Total EST in pool
Brain	25	28/1092524
Bone marrow	82	4/48711
Mouth	60	4/66139
Vascular	58	3/51637
Spleen	56	3/53365
Mammary gland	52	8/151228
Esophagus	49	1/20152
Larynx	42	1/23489
Trachea	38	2/51769
Muscle	37	4/106323
Testes	33	11/327305

^[10]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000125962 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000072969 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "BLAT". UCSC Genome Bioinformatics.
1 2 3 "ARMCX5". Gene cards.
1 2 "NCBI- nucleotide".
↑ "NCBI BLAST".
↑ "NCBI-protein".
↑ "NCBI-EST profiles".{{cite web}}: CS1 maint: deprecated archival service (link)

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000125962 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000072969 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "BLAT". UCSC Genome Bioinformatics.

[genecards-6] 1 2 3 "ARMCX5". Gene cards.

[NCBI-_nucleotide-7] 1 2 "NCBI- nucleotide".

[8] "NCBI BLAST".

[9] "NCBI-protein".

[10] "NCBI-EST profiles".{{cite web}}: CS1 maint: deprecated archival service (link)

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