3-Chloro-4-fluorophenylpiperazine

3-Chloro-4-fluorophenylpiperazine
Clinical data
ATC code	none;
Identifiers
	IUPAC name 1-(3-chloro-4-fluorophenyl)piperazine;
CAS Number	91532-33-1 ; 95884-48-3 (hydrochloride);
PubChem CID	2779263;
ChemSpider	2059498;
UNII	RQS83M82Q6;
CompTox Dashboard (EPA)	DTXSID70381353 ;
ECHA InfoCard	100.337.145
Chemical and physical data
Formula	C10H12ClFN2
Molar mass	214.67 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CN(CCN1)C2=CC(=C(C=C2)F)Cl;
	InChI InChI=1S/C10H12ClFN2/c11-9-7-8(1-2-10(9)12)14-5-3-13-4-6-14/h1-2,7,13H,3-6H2; Key:MKXFXPRJCBUTLX-UHFFFAOYSA-N;

3-Chloro-4-fluorophenylpiperazine (3,4-CFP, Kleferein) is a psychoactive drug of the phenylpiperazine class. It has been sold as a designer drug, first being identified in Poland in 2019.^[1]^[2]

References

↑ Karta oceny substancji 3,4-CFP (kleferein)
↑ "Клефереин (3,4-CFP)". АИПСИН (in Russian). Retrieved 1 January 2026.

[1] Karta oceny substancji 3,4-CFP (kleferein)

[Aipsin-2] "Клефереин (3,4-CFP)". АИПСИН (in Russian). Retrieved 1 January 2026.

[1]

[2]

v t e Arylpiperazines
Phenylpiperazines	1-Phenylpiperazine (1-PP; PP) 3,4-CFP 2C-B-PP Acaprazine Antrafenine Aripiprazole Batoprazine Bifeprunox BRL-15,572 Ciprofloxacin Dapiprazole DCPP DMPP Diphenylpiperazine Dropropizine EGIS-7625 EGIS-12,233 Elopiprazole Eltoprazine Enpiprazole Ensaculin Etoperidone Flesinoxan Fluanisone Flibanserin Fluprazine Itraconazole Ketoconazole Levodropropizine Lorpiprazole mCPP Mefway MeOPP Mepiprazole Naftopidil Naluzotan Nefazodone Niaprazine Oxypertine Pardoprunox pCPP pFPP Posaconazole S-14,506 S-14,671 S-15,535 SB-258,585 SB-271,046 SB-357,134 SB-399,885 Sonepiprazole TFMPP Tolpiprazole Trazodone Urapidil Vesnarinone Vilazodone Vortioxetine WAY-100,135 WAY-100,635
Benzylpiperazines	2C-B-BZP 3-Methylbenzylpiperazine Befuraline Bifeprunox Buclizine BZP Chlorbenzoxamine DBZP EGIS-7625 Fipexide Imatinib MBZP MDBZP Meclozine Methoxypiperamide NSI-189 Piberaline Piribedil RN-1747 Sunifiram Trimetazidine Vesnarinone
Naphthylpiperazines	1-Naphthylpiperazine (1-NP) 2-Naphthylpiperazine (2-NP; 1-deazaquipazine) CSP-2503 F-11,461 S-14,506 S-14671
Quinolinylpiperazines	FPPQ 6-Nitroquipazine Isoquipazine Quipazine VCU-1021 (3-methoxyquipazine)
Diphenylalkylpiperazines	AD-1211 Almitrine Amperozide BRL-15,572 Buclizine BW373U86 Cetirizine Chlorbenzoxamine Chlorcyclizine Cinnarizine Clocinizine Cyclizine DBL-583 Diphenpipenol Diphenylmethylpiperazine Dotarizine DPI-221 DPI-287 DPI-3290 GBR-12,783 GBR-12,935 GBR-13,069 GBR-13,098 GBR-13,119 Hydroxyzine JJC8-088 Lidoflazine Manidipine Meclozine MT-45 Oxatomide SNC-80 Vanoxerine
Pyrimidinylpiperazines	Buspirone Dasatinib Eptapirone Gepirone Ipsapirone Piribedil Pyrimidinylpiperazine Revospirone Tandospirone Tirilazad Trimazosin Umespirone Zalospirone
Pyridinylpiperazines	Atevirdine Azaperone Delavirdine Mirtazapine ORG-12962 Pyridinylpiperazine
Benzo(iso)thiazolyl piperazines	Lurasidone Perospirone Revospirone Tiospirone Ziprasidone
Tricyclic-linked piperazines	Amoxapine Clopenthixol Clorotepine Clozapine Cyanothepin Doclothepin Docloxythepin Flupentixol Fluphenazine Isofloxythepin Loxapine Meperathiepin Metitepine Octomethothepin Olanzapine Opipramol Oxyclothepin Oxyprothepin Peradithiepin Perathiepin Perazine Perphenazine Pirenzepine Prochlorperazine Thiethylperazine Thiothixene Trifluoperazine Trifluthepin Zuclopenthixol
Others/uncategorized	AP-238 Azimilide Bucinnazine Cinepazet Cinepazic acid Cinepazide CPD-1 Cyclohexylpiperazine Hexocyclium Indinavir JNJ-7777120 Lodenafil MK-212 Mirodenafil PB-28 Ranolazine SA-4503 Sildenafil Tadalafil Vardenafil VCU-1012 VUF-6002 WY-46824 Zipeprol ZINC000443438219

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3-Chloro-4-fluorophenylpiperazine

See also

References