ZDHHC2

ZDHHC2
Identifiers
Aliases	ZDHHC2, DHHC2, ZNF372, zinc finger DHHC-type containing 2, zinc finger DHHC-type palmitoyltransferase 2
External IDs	MGI: 1923452; GeneCards: ZDHHC2
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.3.1.225 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 8 (human) Band 8p22 Start 17,156,482 bp End 17,224,799 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 A4 Start 40,876,856 bp End 40,963,309 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm retinal pigment epithelium pancreatic epithelial cell tibialis anterior muscle mucosa of ileum Skeletal muscle tissue of rectus abdominis biceps brachii spinal ganglia renal medulla deltoid muscle Top expressed in cranial nervi trigeminal nerve islet of Langerhans barrel cortex lumbar spinal ganglion autonomic nerve plexus parasympathetic nervous system ventromedial nucleus retinal pigment epithelium trigeminal ganglion More reference expression data BioGPS n/a
Gene ontology Molecular function protein-cysteine S-palmitoyltransferase activity transferase activity acyltransferase activity palmitoyltransferase activity Cellular component integral component of membrane plasma membrane Golgi apparatus recycling endosome membrane integral component of plasma membrane endoplasmic reticulum membrane Biological process protein palmitoylation protein targeting to membrane peptidyl-L-cysteine S-palmitoylation Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 51201 70546 Ensembl ENSG00000104219 ENSMUSG00000039470 UniProt Q9UIJ5 P59267 RefSeq (mRNA) NM_016353 NM_001362988 NM_001362989 NM_178395 NM_001357249 RefSeq (protein) NP_057437 NP_001349917 NP_001349918 NP_848482 NP_001344178 Location (UCSC) Chr 8: 17.16 – 17.22 Mb Chr 8: 40.88 – 40.96 Mb PubMed search
Wikidata
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Zinc finger, also known as ZDHHC2, is a human gene.

Further reading

• Zhang J, Planey SL, Ceballos C, et al. (2008). "Identification of CKAP4/p63 as a major substrate of the palmitoyl acyltransferase DHHC2, a putative tumor suppressor, using a novel proteomics method". Mol. Cell. Proteomics. 7 (7): 1378–88. doi:10.1074/mcp.M800069-MCP200. PMC 2493380. PMID 18296695.
• Li B, Cong F, Tan CP, et al. (2002). "Aph2, a protein with a zf-DHHC motif, interacts with c-Abl and has pro-apoptotic activity". J. Biol. Chem. 277 (32): 28870–6. doi:10.1074/jbc.M202388200. PMID 12021275.
• Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Oyama T, Miyoshi Y, Koyama K, et al. (2000). "Isolation of a novel gene on 8p21.3-22 whose expression is reduced significantly in human colorectal cancers with liver metastasis". Genes Chromosomes Cancer. 29 (1): 9–15. doi:10.1002/1098-2264(2000)9999:9999<::AID-GCC1001>3.0.CO;2-#. PMID 10918388. S2CID 196588297.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ravasi T, Suzuki H, Cannistraci CV, et al. (2010). "An atlas of combinatorial transcriptional regulation in mouse and man". Cell. 140 (5): 744–52. doi:10.1016/j.cell.2010.01.044. PMC 2836267. PMID 20211142.
• Planey SL, Keay SK, Zhang CO, Zacharias DA (2009). "Palmitoylation of cytoskeleton associated protein 4 by DHHC2 regulates antiproliferative factor-mediated signaling". Mol. Biol. Cell. 20 (5): 1454–63. doi:10.1091/mbc.E08-08-0849. PMC 2649263. PMID 19144824.
• Sharma C, Yang XH, Hemler ME (2008). "DHHC2 affects palmitoylation, stability, and functions of tetraspanins CD9 and CD151". Mol. Biol. Cell. 19 (8): 3415–25. doi:10.1091/mbc.E07-11-1164. PMC 2488315. PMID 18508921.