// Workers AI · dad joke modeWhat did ZDHHC17 gene say? "I'm zinc-ing of you

ZDHHC17
Identifiers
Aliases	ZDHHC17, HIP14, HIP3, HYPH, HSPC294, zinc finger DHHC-type containing 17, DHHC-17, zinc finger DHHC-type palmitoyltransferase 17, DHHC17
External IDs	OMIM: 607799; MGI: 2445110; HomoloGene: 56324; GeneCards: ZDHHC17; OMA:ZDHHC17 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3EU9
Enzyme activity
Gene location (Human)
Chr.	Chromosome 12 (human)
End	76,853,696 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	110,846,001 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; cerebellar vermis; ; Brodmann area 23; ; lateral nuclear group of thalamus; ; external globus pallidus; ; pars compacta; ; superior vestibular nucleus; ; pars reticulata; ; subthalamic nucleus; ; pons;
	Top expressed in
	neural layer of retina; ; gastrula; ; Rostral migratory stream; ; lobe of cerebellum; ; cerebellar vermis; ; ascending aorta; ; nucleus of stria terminalis; ; otolith organ; ; inferior colliculi; ; utricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-cysteine S-palmitoyltransferase activity; transferase activity; magnesium ion transmembrane transporter activity; signal transducer activity; palmitoyltransferase activity; protein binding; identical protein binding; acyltransferase activity;
Cellular component	integral component of membrane; Golgi apparatus; intracellular membrane-bounded organelle; membrane; Golgi membrane; Golgi-associated vesicle membrane; cytoplasmic vesicle membrane; cytoplasmic vesicle; presynaptic membrane; plasma membrane; synapse; cell junction; cytosol;
Biological process	protein palmitoylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; lipoprotein transport; signal transduction; magnesium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	23390
	320150
	ENSG00000186908
	ENSMUSG00000035798
	Q8IUH5
	Q80TN5
	NM_015336; NM_001359626
	NM_172554; NM_001359622; NM_001359624
	NP_056151; NP_001346555
	NP_766142; NP_001346551; NP_001346553
	Wikidata
View/Edit Human	View/Edit Mouse

Palmitoyltransferase ZDHHC17 is an enzyme that contains a DHHC domain that in humans is encoded by the ZDHHC17 gene.^[5]^[6]^[7]

Interactions

ZDHHC17 has been shown to interact with Huntingtin.^[8]^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000186908 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035798 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (Sep 1998). "Huntingtin interacts with a family of WW domain proteins". Human Molecular Genetics. 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. PMID 9700202.
↑ Goytain A, Hines RM, Quamme GA (Nov 2008). "Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport". The Journal of Biological Chemistry. 283 (48): 33365–74. doi:10.1074/jbc.M801469200. PMC 2662264. PMID 18794299.
↑ "Entrez Gene: ZDHHC17 zinc finger, DHHC-type containing 17".
↑ Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (Sep 1998). "Huntingtin interacts with a family of WW domain proteins". Human Molecular Genetics. 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. PMID 9700202.
↑ Singaraja RR, Hadano S, Metzler M, Givan S, Wellington CL, Warby S, Yanai A, Gutekunst CA, Leavitt BR, Yi H, Fichter K, Gan L, McCutcheon K, Chopra V, Michel J, Hersch SM, Ikeda JE, Hayden MR (Nov 2002). "HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis". Human Molecular Genetics. 11 (23): 2815–28. doi:10.1093/hmg/11.23.2815. PMID 12393793.

Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
Singaraja RR, Hadano S, Metzler M, Givan S, Wellington CL, Warby S, Yanai A, Gutekunst CA, Leavitt BR, Yi H, Fichter K, Gan L, McCutcheon K, Chopra V, Michel J, Hersch SM, Ikeda JE, Hayden MR (Nov 2002). "HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis". Human Molecular Genetics. 11 (23): 2815–28. doi:10.1093/hmg/11.23.2815. PMID 12393793.
Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501. S2CID 38880905.
Ducker CE, Stettler EM, French KJ, Upson JJ, Smith CD (Dec 2004). "Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase". Oncogene. 23 (57): 9230–7. doi:10.1038/sj.onc.1208171. PMC 2908390. PMID 15489887.
Huang K, Yanai A, Kang R, Arstikaitis P, Singaraja RR, Metzler M, Mullard A, Haigh B, Gauthier-Campbell C, Gutekunst CA, Hayden MR, El-Husseini A (Dec 2004). "Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins". Neuron. 44 (6): 977–86. doi:10.1016/j.neuron.2004.11.027. PMID 15603740. S2CID 14406733.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000186908 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035798 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9700202-5] Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (Sep 1998). "Huntingtin interacts with a family of WW domain proteins". Human Molecular Genetics. 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. PMID 9700202.

[pmid18794299-6] Goytain A, Hines RM, Quamme GA (Nov 2008). "Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport". The Journal of Biological Chemistry. 283 (48): 33365–74. doi:10.1074/jbc.M801469200. PMC 2662264. PMID 18794299.

[entrez-7] "Entrez Gene: ZDHHC17 zinc finger, DHHC-type containing 17".

[autogenerated1-8] Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (Sep 1998). "Huntingtin interacts with a family of WW domain proteins". Human Molecular Genetics. 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. PMID 9700202.

[pmid12393793-9] Singaraja RR, Hadano S, Metzler M, Givan S, Wellington CL, Warby S, Yanai A, Gutekunst CA, Leavitt BR, Yi H, Fichter K, Gan L, McCutcheon K, Chopra V, Michel J, Hersch SM, Ikeda JE, Hayden MR (Nov 2002). "HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis". Human Molecular Genetics. 11 (23): 2815–28. doi:10.1093/hmg/11.23.2815. PMID 12393793.

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// Workers AI · dad joke modeWhat did ZDHHC17 gene say? "I'm zinc-ing of you

Interactions

References

Further reading