// Workers AI · dad joke modeWhy did YY1AP1 go to therapy? It had a gene-ius issue.

YY1AP1
Identifiers
Aliases	YY1AP1, HCCA1, HCCA2, YAP, YY1AP, YY1 associated protein 1, GRNG
External IDs	OMIM: 607860; HomoloGene: 130398; GeneCards: YY1AP1; OMA:YY1AP1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q22 Start 155,659,443 bp End 155,689,000 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon oocyte secondary oocyte right testis left testis blood corpus callosum gastrocnemius muscle mucosa of pharynx saphenous vein n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm nucleus fibrillar center Ino80 complex nucleoplasm nucleolus Biological process regulation of transcription, DNA-templated transcription, DNA-templated cell differentiation regulation of cell cycle cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55249 n/a Ensembl ENSG00000163374 n/a UniProt Q9H869 n/a RefSeq (mRNA) NM_001198899 NM_001198900 NM_001198901 NM_001198902 NM_001198903 NM_001198904 NM_001198905 NM_001198906 NM_018253 NM_139118 NM_139119 NM_139120 NM_139121 n/a RefSeq (protein) NP_001185828 NP_001185829 NP_001185830 NP_001185831 NP_001185832 NP_001185833 NP_001185834 NP_001185835 NP_060723 NP_620829 NP_620830 NP_620832 n/a Location (UCSC) Chr 1: 155.66 – 155.69 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

YY1-associated protein 1 is a protein that in humans is encoded by the YY1AP1 gene.

The encoded gene product presumably interacts with YY1 protein; however, its exact function is not known. Alternative splicing results in multiple transcript variants encoding different isoforms.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Wang Z, Hu G, Wang H, Wu M (2002). "[Clone of a novel liver cancer associated gene and analysis of the secondary structures of the predicted protein]". Zhonghua Gan Zang Bing Za Zhi. 10 (1): 25–7. PMID 11856496.
• Zeng JZ, Wang HY, Chen ZJ, et al. (2002). "Molecular cloning and characterization of a novel gene which is highly expressed in hepatocellular carcinoma". Oncogene. 21 (32): 4932–43. doi:10.1038/sj.onc.1205652. PMID 12118372. S2CID 30899427.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Wang CY, Liang YJ, Lin YS, et al. (2004). "YY1AP, a novel co-activator of YY1". J. Biol. Chem. 279 (17): 17750–5. doi:10.1074/jbc.M310532200. PMID 14744866.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.