YTHDC2

YTHDC2
Identifiers
Aliases	YTHDC2, CAHL, YTH domain containing 2, hYTHDC2
External IDs	OMIM: 616530; MGI: 2448561; HomoloGene: 11265; GeneCards: YTHDC2; OMA:YTHDC2 - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YU6
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 3.6.4.13 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 5 (human) Band 5q22.2 Start 113,513,694 bp End 113,595,285 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 B3 Start 44,960,813 bp End 45,022,791 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell skin of thigh skin of hip hair follicle tibia Achilles tendon Epithelium of choroid plexus epithelium of nasopharynx Brodmann area 23 germinal epithelium Top expressed in secondary oocyte spermatocyte zygote cumulus cell pineal gland semi-lunar valve aortic valve lumbar spinal ganglion endothelial cell of lymphatic vessel tail of embryo More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding protein binding RNA polymerase binding ATP binding hydrolase activity helicase activity nucleic acid binding ATP-dependent activity, acting on RNA RNA binding N6-methyladenosine-containing RNA binding 3'-5' RNA helicase activity Cellular component endoplasmic reticulum cytoplasm nucleus ribonucleoprotein granule Biological process response to tumor necrosis factor RNA processing response to interleukin-1 positive regulation by host of viral genome replication spermatogenesis spermatid development cell differentiation oogenesis oocyte development meiosis germline cell cycle switching, mitotic to meiotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64848 240255 Ensembl ENSG00000047188 ENSMUSG00000034653 UniProt Q9H6S0 B2RR83 RefSeq (mRNA) NM_022828 NM_001345975 NM_001345976 NM_001163013 RefSeq (protein) NP_001332904 NP_001332905 NP_073739 NP_001156485 Location (UCSC) Chr 5: 113.51 – 113.6 Mb Chr 18: 44.96 – 45.02 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

YTH domain containing 2 is a protein that in humans is encoded by the YTHDC2 gene.

Further reading

• Bhatnagar P, Purvis S, Barron-Casella E, DeBaun MR, Casella JF, Arking DE, Keefer JR (April 2011). "Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients". Journal of Human Genetics. 56 (4): 316–23. doi:10.1038/jhg.2011.12. PMC 5825003. PMID 21326311.
• Morohashi K, Sahara H, Watashi K, Iwabata K, Sunoki T, Kuramochi K, Takakusagi K, Miyashita H, Sato N, Tanabe A, Shimotohno K, Kobayashi S, Sakaguchi K, Sugawara F (April 2011). Klein R (ed.). "Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B". PLOS ONE. 6 (4) e18285. Bibcode:2011PLoSO...618285M. doi:10.1371/journal.pone.0018285. PMC 3084704. PMID 21559518.
• Gano JJ, Simon JA (February 2010). "A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein". Molecular & Cellular Proteomics. 9 (2): 255–70. doi:10.1074/mcp.M900261-MCP200. PMC 2830838. PMID 19875381.