// Workers AI · dad joke modeWhat did YTHDC1 gene say? "I'm a cell-ebrity".
| YTHDC1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | YTHDC1, YT521, YT521-B, YTH domain containing 1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 617283; MGI: 2443713; GeneCards: YTHDC1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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YTH domain-containing protein 1 is a protein that in humans is encoded by the YTHDC1 gene.[5][6][7] YTHDC1 is a nuclear protein involved in splice site selection that localises to YT bodies; dynamic subnuclear compartments, which first appear at the beginning of S-phase in the cell cycle and disperse during mitosis.[8]
Interactions
[edit]YTHDC1 has been shown to interact with:
Role in disease
[edit]Alternative splicing is altered in a number of diseases and is particularly relevant to cancer.
Cancer
[edit]YTHDC1 has been shown to splice mRNA transcripts which have oncological importance, regulating tumour functions such as hypoxia associated vascular endothelial growth factor (VEGF), DNA damage associated breast cancer 1 (BRCA1) and hormonal growth driver; the progesterone receptor (PGR).[12][13]
In prostate cancer, YTHDC1 has also been shown to interact with the protein metadherin, encoded by the oncogene MTDH acting to influence alternative splicing of tumour-related genes such as CD44.[11][14]
See also
[edit]References
[edit]- 1 2 3 ENSG00000083896 GRCh38: Ensembl release 89: ENSG00000275272, ENSG00000083896 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035851 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Stoilov P, Rafalska I, Stamm S (October 2002). "YTH: a new domain in nuclear proteins". Trends in Biochemical Sciences. 27 (10): 495–497. doi:10.1016/S0968-0004(02)02189-8. PMID 12368078.
- 1 2 Hartmann AM, Nayler O, Schwaiger FW, Obermeier A, Stamm S (December 1999). "The interaction and colocalization of Sam68 with the splicing-associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59(fyn)". Molecular Biology of the Cell. 10 (11): 3909–3926. doi:10.1091/mbc.10.11.3909. PMC 25688. PMID 10564280.
- ↑ "Entrez Gene: YTHDC1 YTH domain containing 1".
- ↑ Nayler O, Hartmann AM, Stamm S (September 2000). "The ER repeat protein YT521-B localizes to a novel subnuclear compartment". The Journal of Cell Biology. 150 (5): 949–962. doi:10.1083/jcb.150.5.949. PMC 2175241. PMID 10973987.
- 1 2 Rafalska I, Zhang Z, Benderska N, Wolff H, Hartmann AM, Brack-Werner R, et al. (August 2004). "The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation". Human Molecular Genetics. 13 (15): 1535–1549. doi:10.1093/hmg/ddh167. PMID 15175272.
- ↑ Wilkinson FL, Holaska JM, Zhang Z, Sharma A, Manilal S, Holt I, et al. (June 2003). "Emerin interacts in vitro with the splicing-associated factor, YT521-B". European Journal of Biochemistry. 270 (11): 2459–2466. doi:10.1046/j.1432-1033.2003.03617.x. PMID 12755701.
- 1 2 Luxton HJ, Simpson BS, Mills IG, Brindle NR, Ahmed Z, Stavrinides V, et al. (August 2019). "The Oncogene Metadherin Interacts with the Known Splicing Proteins YTHDC1, Sam68 and T-STAR and Plays a Novel Role in Alternative mRNA Splicing". Cancers. 11 (9). Basel: 1233. doi:10.3390/cancers11091233. PMC 6770463. PMID 31450747.
- ↑ Hirschfeld M, Zhang B, Jaeger M, Stamm S, Erbes T, Mayer S, et al. (November 2014). "Hypoxia-dependent mRNA expression pattern of splicing factor YT521 and its impact on oncological important target gene expression". Molecular Carcinogenesis. 53 (11): 883–892. doi:10.1002/mc.22045. PMID 23765422. S2CID 35669580.
- ↑ Zhang B, Shao X, Zhou J, Qiu J, Wu Y, Cheng J (December 2016). "YT521 promotes metastases of endometrial cancer by differential splicing of vascular endothelial growth factor A". Tumour Biology. 37 (12): 15543–15549. doi:10.1007/s13277-015-3908-y. PMID 26289848. S2CID 11257001.
- ↑ Yoo BK, Emdad L, Su ZZ, Villanueva A, Chiang DY, Mukhopadhyay ND, et al. (March 2009). "Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression". The Journal of Clinical Investigation. 119 (3): 465–477. doi:10.1172/JCI36460. PMC 2648696. PMID 19221438.
Further reading
[edit]- Imai Y, Matsuo N, Ogawa S, Tohyama M, Takagi T (1998). "Cloning of a gene, YT521, for a novel RNA splicing-related protein induced by hypoxia/reoxygenation". Brain Research. Molecular Brain Research. 53 (1–2): 33–40. doi:10.1016/S0169-328X(97)00262-3. PMID 9473574.
- Stoss O, Olbrich M, Hartmann AM, Konig H, Memmott J, Andreadis A, et al. (2001). "The STAR/GSG family protein rSLM-2 regulates the selection of alternative splice sites". The Journal of Biological Chemistry. 276 (12): 8665–8673. doi:10.1074/jbc.M006851200. PMID 11118435.
- Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Research. 8 (6): 319–327. doi:10.1093/dnares/8.6.319. PMID 11853319.
- Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Stoss O, Novoyatleva T, Gencheva M, Olbrich M, Benderska N, Stamm S (2005). "p59(fyn)-mediated phosphorylation regulates the activity of the tissue-specific splicing factor rSLM-1". Molecular and Cellular Neurosciences. 27 (1): 8–21. doi:10.1016/j.mcn.2004.04.011. PMID 15345239. S2CID 31339890.
- Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–5396. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
- Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
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