WDR83

WDR83
Identifiers
Aliases	WDR83, MORG1, WD repeat domain 83
External IDs	OMIM: 616850; MGI: 1915086; HomoloGene: 12194; GeneCards: WDR83; OMA:WDR83 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.13 Start 12,666,802 bp End 12,675,832 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 C3 Start 85,801,664 bp End 85,807,935 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum prefrontal cortex right frontal lobe Brodmann area 9 granulocyte anterior cingulate cortex apex of heart gonad hypothalamus skin of leg Top expressed in right kidney ventricular zone neural layer of retina proximal tubule dentate gyrus of hippocampal formation granule cell embryo lip embryo primary visual cortex neural tube More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cytoplasm catalytic step 2 spliceosome spliceosomal complex endosome membrane nucleus Biological process mRNA splicing, via spliceosome RNA splicing, via transesterification reactions mRNA processing MAPK cascade RNA splicing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84292 67836 Ensembl ENSG00000123154 ENSMUSG00000005150 UniProt Q9BRX9 Q9DAJ4 RefSeq (mRNA) NM_001099737 NM_032332 NM_026399 RefSeq (protein) NP_001093207 NP_115708 NP_080675 Location (UCSC) Chr 19: 12.67 – 12.68 Mb Chr 8: 85.8 – 85.81 Mb PubMed search
Wikidata
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WD repeat domain 83 is a protein that in humans is encoded by the WDR83 gene.

Function

This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants.

Further reading

• Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4) S1355838202021088: 426–39. doi:10.1017/s1355838202021088. PMC 1370266. PMID 11991638.
• Vomastek T, Schaeffer HJ, Tarcsafalvi A, Smolkin ME, Bissonette EA, Weber MJ (2004). "Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists". Proc. Natl. Acad. Sci. U.S.A. 101 (18): 6981–6. Bibcode:2004PNAS..101.6981V. doi:10.1073/pnas.0305894101. PMC 406452. PMID 15118098.
• Hopfer U, Hopfer H, Jablonski K, Stahl RA, Wolf G (2006). "The novel WD-repeat protein Morg1 acts as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (PHD3)". J. Biol. Chem. 281 (13): 8645–55. doi:10.1074/jbc.M513751200. PMID 16407229.
• Haase D, Keiner S, Mawrin C, Wolf G (2009). "Reduced Morg1 expression in ischemic human brain". Neurosci. Lett. 455 (1): 46–50. doi:10.1016/j.neulet.2009.03.048. PMID 19429104. S2CID 27095825.
• Su WY, Li JT, Cui Y, Hong J, Du W, Wang YC, Lin YW, Xiong H, Wang JL, Kong X, Gao QY, Wei LP, Fang JY (2012). "Bidirectional regulation between WDR83 and its natural antisense transcript DHPS in gastric cancer". Cell Res. 22 (9): 1374–89. doi:10.1038/cr.2012.57. PMC 3434345. PMID 22491477.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.