// Workers AI · dad joke modeDoes WDR5 have a drive? Yes, it's a radio drive.

WDR5
Identifiers
Aliases	WDR5, BIG-3, CFAP89, SWD3, WD repeat-containing protein 5, WD repeat domain 5
External IDs	OMIM: 609012; MGI: 2155884; GeneCards: WDR5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CNX, 2CO0, 2G99, 2G9A, 2GNQ, 2H13, 2H14, 2H68, 2H6K, 2H6N, 2H6Q, 2H9L, 2H9M, 2H9N, 2H9P, 2O9K, 3EG6, 3EMH, 3MXX, 3N0D, 3N0E, 3P4F, 3PSL, 3SMR, 3UR4, 3UVK, 3UVL, 3UVM, 3UVN, 3UVO, 4A7J, 4CY1, 4CY2, 4ERQ, 4ERY, 4ERZ, 4ES0, 4ESG, 4EWR, 4GM3, 4GM8, 4GM9, 4GMB, 4IA9, 4O45, 4QL1, 4Y7R, 5EAL, 5EAP, 5EAR, 4QQE, 5EAM
Gene location (Human)
Chr.	Chromosome 9 (human)
End	134,159,968 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	27,426,547 bp
RNA expression pattern
	Top expressed in
	skin of arm; ; left testis; ; right testis; ; sperm; ; gastrocnemius muscle; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; anterior pituitary; ; secondary oocyte; ; gonad;
	Top expressed in
	secondary oocyte; ; primary oocyte; ; zygote; ; primitive streak; ; medullary collecting duct; ; epiblast; ; granulocyte; ; renal corpuscle; ; somite; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	histone methyltransferase activity (H3-K4 specific); histone acetyltransferase activity (H4-K8 specific); histone acetyltransferase activity (H4-K5 specific); methylated histone binding; protein binding; histone acetyltransferase activity (H4-K16 specific); histone-lysine N-methyltransferase activity; histone binding;
Cellular component	Set1C/COMPASS complex; intracellular anatomical structure; nucleoplasm; MLL1 complex; MLL3/4 complex; histone acetyltransferase complex; nucleus; histone methyltransferase complex; ciliary basal body;
Biological process	skeletal system development; regulation of transcription, DNA-templated; transcription, DNA-templated; histone H4-K5 acetylation; histone H3-K4 methylation; histone H3 acetylation; histone H4-K16 acetylation; neuron projection development; histone H4-K8 acetylation; cilium assembly; post-translational protein modification; regulation of megakaryocyte differentiation; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	11091
	140858
	ENSG00000196363
	ENSMUSG00000026917
	P61964
	P61965
	NM_017588; NM_052821
	NM_080848
	NP_060058; NP_438172
	NP_543124
	Wikidata
View/Edit Human	View/Edit Mouse

WD repeat-containing protein 5 is a protein that in humans is encoded by the WDR5 gene.^[5]^[6]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.^[6]

Interactions

WDR5 has been shown to interact with Host cell factor C1^[7]^[8] and MLL.^[7] It also interacts with the long non-coding RNA HOTTIP and to the lncRNA NeST.^[9]^[10] WDR5 is a key determinant for MYC recruitment to chromatin^[11]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000196363 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026917 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Gori F, Divieti P, Demay MB (December 2001). "Cloning and characterization of a novel WD-40 repeat protein that dramatically accelerates osteoblastic differentiation". The Journal of Biological Chemistry. 276 (49): 46515–46522. doi:10.1074/jbc.M105757200. PMID 11551928.
1 2 "Entrez Gene: WDR5 WD repeat domain 5".
1 2 Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, et al. (July 2004). "Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression". Molecular and Cellular Biology. 24 (13): 5639–5649. doi:10.1128/MCB.24.13.5639-5649.2004. PMC 480881. PMID 15199122.
↑ Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W (April 2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes & Development. 17 (7): 896–911. doi:10.1101/gad.252103. PMC 196026. PMID 12670868.
↑ Wells AC, Pobezinskaya EL, Pobezinsky LA (April 2020). "Non-coding RNAs in CD8 T cell biology". Molecular Immunology. 120: 67–73. doi:10.1016/j.molimm.2020.01.023. PMC 7093237. PMID 32085976.
↑ Wang KC, Yang YW, Liu B, Sanyal A, Corces-Zimmerman R, Chen Y, et al. (April 2011). "A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression". Nature. 472 (7341): 120–124. Bibcode:2011Natur.472..120W. doi:10.1038/nature09819. PMC 3670758. PMID 21423168.
↑ Thomas LR, Wang Q, Grieb BC, Phan J, Foshage AM, Sun Q, et al. (May 2015). "Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYC". Molecular Cell. 58 (3): 440–452. doi:10.1016/j.molcel.2015.02.028. PMC 4427524. PMID 25818646.

Gori F, Demay MB (2004). "BIG-3, a novel WD-40 repeat protein, is expressed in the developing growth plate and accelerates chondrocyte differentiation in vitro". Endocrinology. 145 (3): 1050–1054. doi:10.1210/en.2003-1314. PMID 14657013.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, et al. (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Wysocka J, Swigut T, Milne TA, Dou Y, Zhang X, Burlingame AL, et al. (June 2005). "WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development". Cell. 121 (6): 859–872. doi:10.1016/j.cell.2005.03.036. PMID 15960974. S2CID 17521631.
Dou Y, Milne TA, Tackett AJ, Smith ER, Fukuda A, Wysocka J, et al. (June 2005). "Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF". Cell. 121 (6): 873–885. doi:10.1016/j.cell.2005.04.031. PMID 15960975. S2CID 14717470.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gori F, Friedman L, Demay MB (2006). "Wdr5, a novel WD repeat protein, regulates osteoblast and chondrocyte differentiation in vivo". Journal of Musculoskeletal & Neuronal Interactions. 5 (4): 338–339. PMID 16340128.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, et al. (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–814. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Ruthenburg AJ, Wang W, Graybosch DM, Li H, Allis CD, Patel DJ, et al. (August 2006). "Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex". Nature Structural & Molecular Biology. 13 (8): 704–712. doi:10.1038/nsmb1119. PMC 4698793. PMID 16829959.
Couture JF, Collazo E, Trievel RC (2006). "Molecular recognition of histone H3 by the WD40 protein WDR5". Nature Structural & Molecular Biology. 13 (8): 698–703. doi:10.1038/nsmb1116. PMID 16829960. S2CID 26165068.
Dou Y, Milne TA, Ruthenburg AJ, Lee S, Lee JW, Verdine GL, et al. (August 2006). "Regulation of MLL1 H3K4 methyltransferase activity by its core components". Nature Structural & Molecular Biology. 13 (8): 713–719. doi:10.1038/nsmb1128. PMID 16878130. S2CID 12849159.
Schuetz A, Allali-Hassani A, Martín F, Loppnau P, Vedadi M, Bochkarev A, et al. (September 2006). "Structural basis for molecular recognition and presentation of histone H3 by WDR5". The EMBO Journal. 25 (18): 4245–4252. doi:10.1038/sj.emboj.7601316. PMC 1570438. PMID 16946699.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Bryan AF, Wang J, Howard GC, Guarnaccia AD, Woodley CM, Aho ER, et al. (April 2020). "WDR5 is a conserved regulator of protein synthesis gene expression". Nucleic Acids Research. 48 (6): 2924–2941. doi:10.1093/nar/gkaa051. PMC 7102967. PMID 31996893.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000196363 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026917 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Gori_2001-5] Gori F, Divieti P, Demay MB (December 2001). "Cloning and characterization of a novel WD-40 repeat protein that dramatically accelerates osteoblastic differentiation". The Journal of Biological Chemistry. 276 (49): 46515–46522. doi:10.1074/jbc.M105757200. PMID 11551928.

[entrez-6] 1 2 "Entrez Gene: WDR5 WD repeat domain 5".

[Yokoyama_2004-7] 1 2 Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, et al. (July 2004). "Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression". Molecular and Cellular Biology. 24 (13): 5639–5649. doi:10.1128/MCB.24.13.5639-5649.2004. PMC 480881. PMID 15199122.

[Wysocka_2003-8] Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W (April 2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes & Development. 17 (7): 896–911. doi:10.1101/gad.252103. PMC 196026. PMID 12670868.

[9] Wells AC, Pobezinskaya EL, Pobezinsky LA (April 2020). "Non-coding RNAs in CD8 T cell biology". Molecular Immunology. 120: 67–73. doi:10.1016/j.molimm.2020.01.023. PMC 7093237. PMID 32085976.

[Wang_2011-10] Wang KC, Yang YW, Liu B, Sanyal A, Corces-Zimmerman R, Chen Y, et al. (April 2011). "A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression". Nature. 472 (7341): 120–124. Bibcode:2011Natur.472..120W. doi:10.1038/nature09819. PMC 3670758. PMID 21423168.

[11] Thomas LR, Wang Q, Grieb BC, Phan J, Foshage AM, Sun Q, et al. (May 2015). "Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYC". Molecular Cell. 58 (3): 440–452. doi:10.1016/j.molcel.2015.02.028. PMC 4427524. PMID 25818646.

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// Workers AI · dad joke modeDoes WDR5 have a drive? Yes, it's a radio drive.

Interactions

References

Further reading