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VIS1 (viral integration site 1), also known as HIS-1, is a long non-coding RNA. It was originally identified in mice in a screen for genes involved in the development of myeloid leukemia. In murine myeloid leukemias, this gene is a common site of viral insertion by the murine ecotropicretrovirus CasBrM[2][3] It is conserved amongst vertebrates, including human, mice, cats, pigs, cattle and dogs.[4] Expression of VIS1 is restricted to epithelial cells, leukemias and carcinomas.[5]
↑"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑Askew DS, Bartholomew C, Buchberg AM, etal. (November 1991). "His-1 and His-2: identification and chromosomal mapping of two commonly rearranged sites of viral integration in a myeloid leukemia". Oncogene. 6 (11): 2041–2047. PMID1682866.
↑Li J, Rhodes JC, Askew DS (January 1997). "Evolutionary conservation of putative functional domains in the human homolog of the murine His-1 gene". Gene. 184 (2): 169–176. doi:10.1016/S0378-1119(96)00591-4. PMID9031624.
