// Workers AI · dad joke modeWhat did USP22 say to its friend? "You're 22nd to none.

USP22
Identifiers
Aliases	USP22, USP3L, ubiquitin specific peptidase 22
External IDs	OMIM: 612116; MGI: 2144157; HomoloGene: 52664; GeneCards: USP22; OMA:USP22 - orthologs
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 3.4.19.12 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 17 (human) Band 17p11.2 Start 20,999,596 bp End 21,043,760 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 B2 Start 61,042,611 bp End 61,065,881 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in paraflocculus of cerebellum ganglionic eminence middle frontal gyrus frontal pole stromal cell of endometrium Brodmann area 10 ventricular zone right hemisphere of cerebellum cingulate gyrus anterior cingulate cortex Top expressed in ganglionic eminence medial ganglionic eminence paraventricular nucleus of hypothalamus arcuate nucleus dentate gyrus of hippocampal formation granule cell dorsomedial hypothalamic nucleus ventromedial nucleus medial geniculate nucleus anterior amygdaloid area subiculum More reference expression data BioGPS n/a
Gene ontology Molecular function cysteine-type peptidase activity transcription coactivator activity zinc ion binding H4 histone acetyltransferase activity metal ion binding peptidase activity protein binding nuclear receptor coactivator activity thiol-dependent deubiquitinase enzyme binding hydrolase activity Cellular component SAGA-type complex SAGA complex nucleus nucleoplasm nuclear speck Biological process regulation of transcription, DNA-templated ubiquitin-dependent protein catabolic process positive regulation of mitotic cell cycle transcription, DNA-templated proteolysis positive regulation of transcription, DNA-templated histone deubiquitination cell cycle histone ubiquitination histone H4 acetylation protein deubiquitination embryo development ending in birth or egg hatching chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23326 216825 Ensembl ENSG00000124422 ENSMUSG00000042506 UniProt Q9UPT9 Q5DU02 RefSeq (mRNA) NM_015276 NM_001004143 RefSeq (protein) NP_056091 NP_001004143 Location (UCSC) Chr 17: 21 – 21.04 Mb Chr 11: 61.04 – 61.07 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin specific peptidase 22 is a protein that in humans is encoded by the USP22 gene on chromosome 17. USP22 is known to function as a histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA.

Further reading

• Lang G, Bonnet J, Umlauf D, Karmodiya K, Koffler J, Stierle M, Devys D, Tora L (September 2011). "The tightly controlled deubiquitination activity of the human SAGA complex differentially modifies distinct gene regulatory elements". Molecular and Cellular Biology. 31 (18): 3734–44. doi:10.1128/MCB.05231-11. PMC 3165722. PMID 21746879.
• Wang YL, Faiola F, Xu M, Pan S, Martinez E (December 2008). "Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein". The Journal of Biological Chemistry. 283 (49): 33808–15. doi:10.1074/jbc.M806936200. PMC 2590711. PMID 18838386.
• Armour SM, Bennett EJ, Braun CR, Zhang XY, McMahon SB, Gygi SP, Harper JW, Sinclair DA (April 2013). "A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex". Molecular and Cellular Biology. 33 (8): 1487–502. doi:10.1128/MCB.00971-12. PMC 3624249. PMID 23382074.
• Zhang Y, Yao L, Zhang X, Ji H, Wang L, Sun S, Pang D (August 2011). "Elevated expression of USP22 in correlation with poor prognosis in patients with invasive breast cancer". Journal of Cancer Research and Clinical Oncology. 137 (8): 1245–53. doi:10.1007/s00432-011-0998-9. PMC 11827975. PMID 21691749. S2CID 9026376.
• Ling SB, Sun DG, Tang B, Guo C, Zhang Y, Liang R, Wang LM (December 2012). "Knock-down of USP22 by small interfering RNA interference inhibits HepG2 cell proliferation and induces cell cycle arrest". Cellular and Molecular Biology. 58 Suppl: OL1803-8. PMID 23217440.
• Xiong J, Che X, Li X, Yu H, Gong Z, Li W (2012). Semsey S (ed.). "Cloning and characterization of the human USP22 gene promoter". PLOS ONE. 7 (12) e52716. Bibcode:2012PLoSO...752716X. doi:10.1371/journal.pone.0052716. PMC 3530469. PMID 23300749.
• Glinsky GV, Berezovska O, Glinskii AB (June 2005). "Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer". The Journal of Clinical Investigation. 115 (6): 1503–21. doi:10.1172/JCI23412. PMC 1136989. PMID 15931389.
• Xu H, Liu YL, Yang YM, Dong XS (January 2012). "Knock-down of ubiquitin-specific protease 22 by micro-RNA interference inhibits colorectal cancer growth". International Journal of Colorectal Disease. 27 (1): 21–30. doi:10.1007/s00384-011-1275-8. PMID 21773699. S2CID 25987858.
• Liu YL, Yang YM, Xu H, Dong XS (March 2011). "Aberrant expression of USP22 is associated with liver metastasis and poor prognosis of colorectal cancer". Journal of Surgical Oncology. 103 (3): 283–9. doi:10.1002/jso.21802. PMID 21337558. S2CID 30706374.