// Workers AI · dad joke modeWhat did USE1 say to USE2? Let's use each other.

USE1
Identifiers
Aliases	USE1, P31, SLT1, D12, MDS032, unconventional SNARE in the ER 1
External IDs	OMIM: 610675; MGI: 1914273; HomoloGene: 10214; GeneCards: USE1; OMA:USE1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.11 Start 17,215,346 bp End 17,219,829 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 B3.3 Start 71,819,492 bp End 71,822,376 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii anterior cingulate cortex apex of heart prefrontal cortex amygdala right frontal lobe C1 segment putamen nucleus accumbens Brodmann area 9 Top expressed in superior surface of tongue transitional epithelium of urinary bladder supraoptic nucleus vestibular sensory epithelium interventricular septum gallbladder right lung lobe skin of external ear seminal vesicula corneal stroma More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane lysosome endoplasmic reticulum membrane endoplasmic reticulum membrane Biological process lysosomal transport protein transport endoplasmic reticulum to Golgi vesicle-mediated transport protein catabolic process vesicle-mediated transport secretion by cell retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55850 67023 Ensembl ENSG00000053501 ENSMUSG00000002395 UniProt Q9NZ43 Q9CQ56 RefSeq (mRNA) NM_018467 NM_001145780 NM_025917 NM_029768 RefSeq (protein) NP_060937 NP_001139252 NP_080193 Location (UCSC) Chr 19: 17.22 – 17.22 Mb Chr 8: 71.82 – 71.82 Mb PubMed search
Wikidata
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Uncharacterized hematopoietic stem/progenitor cells protein MDS032, also known as MDS032, is a protein which in humans is encoded by the MDS032 gene.

Function

D12, the mouse homolog of MDS032, is a SNARE protein involved with the Golgi secretory apparatus and with endosome-lysosome transport.

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501. S2CID 38880905.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Hirose H, Arasaki K, Dohmae N, et al. (2005). "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi". EMBO J. 23 (6): 1267–78. doi:10.1038/sj.emboj.7600135. PMC 381410. PMID 15029241.
• Nakajima K, Hirose H, Taniguchi M, et al. (2005). "Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion". EMBO J. 23 (16): 3216–26. doi:10.1038/sj.emboj.7600333. PMC 514507. PMID 15272311.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Okumura AJ, Hatsuzawa K, Tamura T, et al. (2006). "Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system". J. Biol. Chem. 281 (7): 4495–506. doi:10.1074/jbc.M509715200. PMID 16354670.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.