// Workers AI · dad joke modeWhat did UNC45A say to its friend? You're a bonded buddy.

UNC45A
Identifiers
Aliases	UNC45A, GC-UNC45, GCUNC-45, GCUNC45, IRO039700, SMAP-1, SMAP1, UNC-45A, unc-45 myosin chaperone A, OOHE
External IDs	OMIM: 611219; MGI: 2142246; HomoloGene: 32423; GeneCards: UNC45A; OMA:UNC45A - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DBA
Gene location (Human) Chr. Chromosome 15 (human) Band 15q26.1 Start 90,930,180 bp End 90,954,093 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 D2 Start 79,975,040 bp End 79,997,741 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in popliteal artery tibial arteries muscle layer of sigmoid colon Descending thoracic aorta ascending aorta right hemisphere of cerebellum body of uterus skin of leg gastric mucosa stromal cell of endometrium Top expressed in external carotid artery mucous cell of stomach internal carotid artery olfactory epithelium lip Rostral migratory stream molar neural layer of retina tunica media of zone of aorta paraventricular nucleus of hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function Hsp90 protein binding protein binding cadherin binding Cellular component cytoplasm perinuclear region of cytoplasm nucleus Golgi apparatus cytosol nuclear speck Biological process multicellular organism development cell differentiation muscle organ development chaperone-mediated protein folding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55898 101869 Ensembl ENSG00000140553 ENSMUSG00000030533 UniProt Q9H3U1 Q99KD5 RefSeq (mRNA) NM_001039675 NM_017979 NM_018671 NM_001323619 NM_001323620 NM_001323621 NM_133952 RefSeq (protein) NP_001034764 NP_001310548 NP_001310549 NP_001310550 NP_061141 NP_598713 Location (UCSC) Chr 15: 90.93 – 90.95 Mb Chr 7: 79.98 – 80 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Protein unc-45 homolog A is a protein that in humans is encoded by the UNC45A gene.

Further reading

• Bazzaro M, Santillan A, Lin Z, et al. (2008). "Myosin II Co-Chaperone General Cell UNC-45 Overexpression Is Associated with Ovarian Cancer, Rapid Proliferation, and Motility". Am. J. Pathol. 171 (5): 1640–9. doi:10.2353/ajpath.2007.070325. PMC 2043524. PMID 17872978.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Chadli A, Graham JD, Abel MG, et al. (2006). "GCUNC-45 Is a Novel Regulator for the Progesterone Receptor/hsp90 Chaperoning Pathway". Mol. Cell. Biol. 26 (5): 1722–30. doi:10.1128/MCB.26.5.1722-1730.2006. PMC 1430258. PMID 16478993.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.