// Workers AI · dad joke modeWhat did UFSP2 say to its friend? "You're a file above the rest.

UFSP2
Identifiers
Aliases	UFSP2, C4orf20, BHD, UFM1-specific peptidase 2, UFM1 specific peptidase 2, SEMDDR
External IDs	OMIM: 611482; MGI: 1913679; HomoloGene: 10151; GeneCards: UFSP2; OMA:UFSP2 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3OQC
Gene location (Human)
Chr.	Chromosome 4 (human)
End	185,425,979 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	46,449,995 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; muscle of thigh; ; triceps brachii muscle; ; left ovary; ; ventricular zone; ; gastrocnemius muscle; ; right ovary; ; Skeletal muscle tissue of rectus abdominis; ; Skeletal muscle tissue of biceps brachii; ; Descending thoracic aorta;
	Top expressed in
	seminal vesicula; ; molar; ; facial motor nucleus; ; medial vestibular nucleus; ; deep cerebellar nuclei; ; pineal gland; ; calvaria; ; right kidney; ; pontine nuclei; ; islet of Langerhans;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; hydrolase activity; cysteine-type peptidase activity; protein binding; thiolester hydrolase activity; UFM1 hydrolase activity;
Cellular component	nucleus; cytoplasm; endoplasmic reticulum;
Biological process	regulation of intracellular estrogen receptor signaling pathway; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	55325
	192169
	ENSG00000109775
	ENSMUSG00000031634
	Q9NUQ7
	Q99K23
	NM_018359
	NM_138668
	NP_060829
	NP_619609
	Wikidata
View/Edit Human	View/Edit Mouse

UFM1 specific peptidase 2 is a protein that in humans is encoded by the UFSP2 gene.^[5]

Function

This gene encodes a highly conserved cysteine protease. The protein cleaves two C-terminal residues from ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein. Activation of ubiquitin-fold modifier 1 by the encoded protein exposes a C-terminal glycine residue that allows interaction with other proteins and transfer to its target protein. An allelic variant of this gene has been associated with Beukes hip dysplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000109775 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031634 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: UFM1 specific peptidase 2". Retrieved 2020-04-15.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by adding missing information.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000109775 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031634 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: UFM1 specific peptidase 2". Retrieved 2020-04-15.

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// Workers AI · dad joke modeWhat did UFSP2 say to its friend? "You're a file above the rest.

Function

References