// Workers AI · dad joke modeWhat did UFSP1 say to UFSP2? You're a byte ahead.

UFSP1
Identifiers
Aliases	UFSP1, UFSP, UFM1-specific peptidase 1 (inactive), UFM1 specific peptidase 1 (inactive)
External IDs	OMIM: 611481; MGI: 1917490; HomoloGene: 80245; GeneCards: UFSP1; OMA:UFSP1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	100,889,715 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	137,293,927 bp
RNA expression pattern
	Top expressed in
	gonad; ; muscle of thigh; ; stromal cell of endometrium; ; gastrocnemius muscle; ; mucosa of transverse colon; ; right adrenal cortex; ; granulocyte; ; left adrenal cortex; ; skeletal muscle tissue; ; right lobe of liver;
	Top expressed in
	bone marrow; ; quadriceps femoris muscle; ; skeletal muscle tissue; ; proximal tubule; ; muscle of thigh; ; thoracic diaphragm; ; striatum of neuraxis; ; neural layer of retina; ; hypothalamus; ; muscle of arm;
	More reference expression data
	n/a
Gene ontology
Molecular function	UFM1 hydrolase activity; cysteine-type peptidase activity; molecular function;
Cellular component	extracellular exosome;
Biological process	proteolysis; biological process;
	Sources:Amigo / QuickGO
Orthologs
	402682
	70240
	ENSG00000176125
	ENSMUSG00000051502
	Q6NVU6
	Q9CZP0
	NM_001015072
	NM_027356
	NP_001015072
	NP_081632
	Wikidata
View/Edit Human	View/Edit Mouse

UFM1 specific peptidase 1 (inactive) is a protein that in humans is encoded by the UFSP1 gene.^[5]

Function

This gene encodes a protein that is similar to other Ufm1-specific proteases. Studies in mouse determined that Ufsp1 releases Ufm1 (ubiquitin-fold modifier 1) from its bound conjugated complexes which also makes it into an active form. Because the human UFSP1 protein is shorter on the N-terminus and lacks a conserved Cys active site, it is predicted to be non-functional.[provided by RefSeq, Nov 2009].^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000176125 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051502 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: UFM1 specific peptidase 1 (inactive)". Retrieved 2020-04-15. This article incorporates text from this source, which is in the public domain.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000176125 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051502 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: UFM1 specific peptidase 1 (inactive)". Retrieved 2020-04-15. This article incorporates text from this source, which is in the public domain.

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// Workers AI · dad joke modeWhat did UFSP1 say to UFSP2? You're a byte ahead.

Function

References