// Workers AI · dad joke modeWhat did UBE3C say to its date? You're a gene-ius match.

UBE3C
Identifiers
Aliases	UBE3C, HECTH2, ubiquitin protein ligase E3C, RAUL
External IDs	OMIM: 614454; MGI: 2140998; HomoloGene: 8783; GeneCards: UBE3C; OMA:UBE3C - orthologs
Enzyme activity
Gene location (Human)
Chr.	Chromosome 7 (human)
End	157,269,370 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	29,881,090 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; Achilles tendon; ; islet of Langerhans; ; epithelium of colon; ; gastrocnemius muscle; ; muscle of thigh; ; stromal cell of endometrium; ; gingival epithelium; ; Skeletal muscle tissue of biceps brachii; ; rectum;
	Top expressed in
	spermatocyte; ; muscle of thigh; ; spermatid; ; dentate gyrus of hippocampal formation granule cell; ; tail of embryo; ; facial motor nucleus; ; triceps brachii muscle; ; cumulus cell; ; trigeminal ganglion; ; primary visual cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; ubiquitin-protein transferase activity; transferase activity; ubiquitin protein ligase activity; ubiquitin conjugating enzyme activity;
Cellular component	proteasome complex; intracellular anatomical structure; nucleus; cytoplasm;
Biological process	protein polyubiquitination; protein ubiquitination; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	9690
	100763
	ENSG00000009335
	ENSMUSG00000039000
	Q15386
	Q80U95
	NM_014671
	NM_133907
	NP_055486
	NP_598668
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-protein ligase E3C is an enzyme that in humans is encoded by the UBE3C gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000009335 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039000 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
↑ You J, Pickart CM (Jun 2001). "A HECT domain E3 enzyme assembles novel polyubiquitin chains". J Biol Chem. 276 (23): 19871–8. doi:10.1074/jbc.M100034200. PMID 11278995.
↑ "Entrez Gene: UBE3C ubiquitin protein ligase E3C".

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
You J, Wang M, Aoki T, et al. (2003). "Proteolytic targeting of transcriptional regulator TIP120B by a HECT domain E3 ligase". J. Biol. Chem. 278 (26): 23369–75. doi:10.1074/jbc.M212887200. PMID 12692129.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000009335 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039000 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7584026-5] Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.

[pmid11278995-6] You J, Pickart CM (Jun 2001). "A HECT domain E3 enzyme assembles novel polyubiquitin chains". J Biol Chem. 276 (23): 19871–8. doi:10.1074/jbc.M100034200. PMID 11278995.

[entrez-7] "Entrez Gene: UBE3C ubiquitin protein ligase E3C".

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// Workers AI · dad joke modeWhat did UBE3C say to its date? You're a gene-ius match.

References

Further reading