// Workers AI · dad joke modeWhat did UBASH3A gene say? "You can't bash my function.

UBASH3A
Identifiers
Aliases	UBASH3A, CLIP4, STS-2, TULA, TULA-1, ubiquitin associated and SH3 domain containing A
External IDs	OMIM: 605736; MGI: 1926074; HomoloGene: 56833; GeneCards: UBASH3A; OMA:UBASH3A - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CRN
Gene location (Human)
Chr.	Chromosome 21 (human)
End	42,447,684 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	31,465,866 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; lymph node; ; testicle; ; thymus; ; spleen; ; appendix; ; gallbladder; ; rectum; ; tonsil;
	Top expressed in
	thymus; ; mesenteric lymph nodes; ; granulocyte; ; blood; ; embryo; ; yolk sac; ; parasympathetic nervous system; ; thyroid gland; ; pharynx; ; tongue;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; phosphatase activity;
Cellular component	cytoplasm; cytosol; extracellular exosome; nucleus; nucleoplasm; Golgi apparatus;
Biological process	regulation of cytokine production; negative regulation of T cell receptor signaling pathway; negative regulation of signal transduction; dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	53347
	328795
	ENSG00000160185
	ENSMUSG00000042345
	P57075
	Q3V3E1
	NM_001001895; NM_001243467; NM_018961
	NM_177823
	NP_001001895; NP_001230396; NP_061834
	NP_808491
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-associated and SH3 domain-containing protein A is a protein that in humans is encoded by the UBASH3A gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000160185 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042345 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wattenhofer M, Shibuya K, Kudoh J, Lyle R, Michaud J, Rossier C, Kawasaki K, Asakawa S, Minoshima S, Berry A, Bonne-Tamir B, Shimizu N, Antonarakis SE, Scott HS (Apr 2001). "Isolation and characterization of the UBASH3A gene on 21q22.3 encoding a potential nuclear protein with a novel combination of domains". Hum Genet. 108 (2): 140–7. doi:10.1007/s004390000453. PMID 11281453. S2CID 22719211.
↑ "Entrez Gene: UBASH3A ubiquitin associated and SH3 domain containing, A".

Smirnova EV, Collingwood TS, Bisbal C, et al. (2008). "TULA proteins bind to ABCE-1, a host factor of HIV-1 assembly, and inhibit HIV-1 biogenesis in a UBA-dependent fashion". Virology. 372 (1): 10–23. doi:10.1016/j.virol.2007.10.012. PMID 18006034.
Collingwood TS, Smirnova EV, Bogush M, et al. (2007). "T-cell ubiquitin ligand affects cell death through a functional interaction with apoptosis-inducing factor, a key factor of caspase-independent apoptosis". J. Biol. Chem. 282 (42): 30920–8. doi:10.1074/jbc.M706870200. PMID 17709377.
Bertelsen V, Breen K, Sandvig K, et al. (2007). "The Cbl-interacting protein TULA inhibits dynamin-dependent endocytosis". Exp. Cell Res. 313 (8): 1696–709. doi:10.1016/j.yexcr.2007.02.017. hdl:10852/28097. PMID 17382318.
Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.
Hoeller D, Crosetto N, Blagoev B, et al. (2006). "Regulation of ubiquitin-binding proteins by monoubiquitination". Nat. Cell Biol. 8 (2): 163–9. doi:10.1038/ncb1354. PMID 16429130. S2CID 1324257.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kowanetz K, Crosetto N, Haglund K, et al. (2004). "Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases". J. Biol. Chem. 279 (31): 32786–95. doi:10.1074/jbc.M403759200. PMID 15159412.
Feshchenko EA, Smirnova EV, Swaminathan G, et al. (2004). "TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin". Oncogene. 23 (27): 4690–706. doi:10.1038/sj.onc.1207627. PMID 15107835. S2CID 34698870.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article on a gene on human chromosome 21 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000160185 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042345 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11281453-5] Wattenhofer M, Shibuya K, Kudoh J, Lyle R, Michaud J, Rossier C, Kawasaki K, Asakawa S, Minoshima S, Berry A, Bonne-Tamir B, Shimizu N, Antonarakis SE, Scott HS (Apr 2001). "Isolation and characterization of the UBASH3A gene on 21q22.3 encoding a potential nuclear protein with a novel combination of domains". Hum Genet. 108 (2): 140–7. doi:10.1007/s004390000453. PMID 11281453. S2CID 22719211.

[entrez-6] "Entrez Gene: UBASH3A ubiquitin associated and SH3 domain containing, A".

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// Workers AI · dad joke modeWhat did UBASH3A gene say? "You can't bash my function.

References

Further reading