Talk:Transthyretin

Low CSF transthyretin in schizophrenia

Low concentration of three peptide fragments of transthyretin in the cerebrospinal fluid has been recently found in schizophrenic patients:

• Potential Biomarkers of First-onset Schizophrenia Found in Cerebrospinal Fluid

--CopperKettle 10:48, 3 December 2006 (UTC)

Whole issue of a journal devoted to transthyretin

There's an year 2002 Issue 12 of "Clinical chemistry and laboratory medicine" devoted mainly to transthyretin. A person with an access could get much information there concerning the history of this protein etc. Would be nice to have a "history" section (discovery, evolution of the protein and so on). CopperKettle 09:10, 19 December 2006 (UTC)

Vitamin-K Dependent? Evidence of post-translational carboxylation

I just found this. Does this mean that vitamin K is implicated in proper functioning of transthyretic and therefore could have something to do with hypothyroidism?

Protein Pept Lett. 2008;15(1):43-6.

Detection of a gamma-carboxy-glutamate as novel post-translational modification of human transthyretin.

Rüggeberg S, Horn P, Li X, Vajkoczy P, Franz T. European Molecular Biology Laboratory, Proteomic Core Facility, Meyerhofstr. 1. 69117 Heidelberg, Germany.

During analysis of the proteome in the cerebrospinal fluid (CSF) of the Caucasian form of moyamoya disease (MMD), a novel post-translational modification of human transthyretin was observed. Two-dimensional electrophoresis and subsequent peptide sequencing with ESI-MS/MS were performed to discover the gamma-carboxylation of the Glu-42 (Gla-42). [PMID 18221012] —Preceding unsigned comment added by 216.9.143.32 (talk) 19:08, 12 May 2008 (UTC)

Malnutrition

An explination is needed as to why transthyretin levels is low during malnutrition. Even if it is one sentence. —Preceding unsigned comment added by 170.232.128.10 (talk) 20:42, 6 February 2011 (UTC)