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Talk:Temporal lobe epilepsy

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Unclear and incorrect items

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Latest comment: 3 years ago1 comment1 person in discussion

This is a false statement and should be removed. Memory is not inside any anatomical structure. Memory function relies on a network of anatomical structures;the dentate gyrus may be an important node of this network.

Declarative memory (memories which can be consciously recalled) is formed in the area of the hippocampus called the dentate gyrus

This is a better statement:

Declarative memory (memories which can be consciously recalled) relies on the hippocampus.

This statement is difficult to understand and should be replaced.

Although the theory is controversial, there is a link between febrile seizures (seizures coinciding with episodes of fever in young children) and subsequent temporal lobe epilepsy, at least epidemiologically.[24][25][26][27]

This is a better statement:

A febrile seizure may increase the risk for developing epilepsy, including temporal lobe epilepsy; the risks for developing epilepsy are 0.5% (no febrile seizure), 1-2% (simple febrile seizure), 6%-8% (complex febrile seizure) and 14% (febrile status epilepticus).[1][2] It is unclear if severe febrile seizures injure the brain leading to epilepsy, or if some children have an intrinsic brain abnormality that predisposes to both febrile seizures and epilepsy.[2]

TMM53 (talk) 05:41, 19 April 2023 (UTC)Reply

Incorrect statement

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Latest comment: 3 years ago1 comment1 person in discussion

The section on "Surgical interventions" and "other treatments" is incorrect because other treatments are actually surgeries. "Scientifically sound" is incorrect; the Wiebe study was important because it was a controlled study. The issue is memory loss, not cognitive function. Experimental anticonvulsant treatment should be distinguished from other treatments because experimental treatment, unlike the other treatments, has uncertain effectiveness and possible severe unknown risks. The correction is:

Surgical interventions

Epilepsy surgery has been performed since the 1860s and doctors have observed that it is highly effective in producing freedom from seizures. However, it was not until 2001 that a controlled study demonstrated the effectiveness of anterior temporal lobectomy.[3] Anterior temporal lobectomy may worsen memory. However, after anterior temporal lobectomy, memory function is supported by the opposite temporal lobe and recruitment of the frontal lobe.[4][5] Cognitive rehabilitation may also help.[6] Other surgical treatments include the vagus nerve stimulator, responsive neurostimulation device, anterior thalamic nucleus stimulator, stereotactic radiosurgery and laser ablation.[7]

Other treatments

The ketogenic diet and modified Atkins diet are additional options.[8][9] Those who have uncontrolled seizures may contribute to improving epilepsy care by participating in experimental drug studies.

TMM53 (talk) 05:42, 19 April 2023 (UTC) TMM53 (talk) 05:42, 19 April 2023 (UTC)Reply

Content conflicts with guideline.

[edit]
Latest comment: 3 years ago1 comment1 person in discussion

Most of this content below does not conform to Wikipedia policy and should be removed. This content can be placed in V. S. Ramachandran. Some content is already on Neuroscience of religion so it is redundant. The content is preserved in the Talk page. If you do not agree, please read the following and it will be obvious why most of the content does not belong:

This is the current content:

Effects on society

The first to record and catalog the abnormal symptoms and signs of TLE was Norman Geschwind. He found a constellation of symptoms that included hypergraphia, hyperreligiosity, collapse, and pedantism, now called Geschwind syndrome.

Vilayanur S. Ramachandran explored the neural basis of the hyperreligiosity seen in TLE using the galvanic skin response (GSR), which correlates with emotional arousal, to determine whether the hyperreligiosity seen in TLE was due to an overall heightened emotional state or was specific to religious stimuli. Ramachandran presented two subjects with neutral, sexually arousing and religious words while measuring GSR. Ramachandran was able to show that patients with TLE showed enhanced emotional responses to the religious words, diminished responses to the sexually charged words, and normal responses to the neutral words. This study was presented as an abstract at a neuroscience conference and referenced in Ramachandran's book, Phantoms in the Brain,[10] but it has never been published in the peer-reviewed scientific press.[11]

A study in 2015, reported that intrinsic religiosity and religiosity outside of organized religion were higher in patients with epilepsy than in the control group.[12] Lower education level, abnormal background EEG activity, and hippocampal sclerosis have been found to be contributing factors for religiosity in TLE.[13]

TLE has been suggested as a materialistic explanation for the revelatory experiences of prominent religious figures such as Abraham, Moses, Jesus, Mohammed, Saint Paul, Joan of Arc,[14] Saint Teresa of Ávila, and Joseph Smith. These experiences are described (in possibly unreliable accounts) as complex interactions with their visions; but possibly (and dependent on the reliability of historical accounts, often made by acolytes) lack the stereotypy, amnestic periods, and automatisms or generalized motor events, which are characteristic of TLE. Psychiatric conditions with psychotic spectrum symptoms might be more plausible physical explanation of these experiences.[15] It has been suggested that Pope Pius IX's doctrine of the immaculate conception was influenced by his forensically diagnosed[jargon] partial epilepsy.[16]

In 2016, a case history found that a male temporal lobe epileptic patient experienced a vision of God following a temporal lobe seizure, while undergoing EEG monitoring. The patient reported that God had sent him to the world to "bring redemption to the people of Israel".[17] The purported link between TLE and religiosity has inspired work by Michael Persinger and other researchers in the field of neurotheology. Others have questioned the evidence for a link between temporal lobe epilepsy and religiosity.[11][18]

This is the proposed revision which will can be placed in Personality section adjacent to Geshwind content:

Other studies have investigated the relationship between religion and epilepsy.[19][20][21][22][23] [24][18]

References

  1. ↑ Eilbert, Wesley; Chan, Chuck (August 2022). "Febrile seizures: A review". Journal of the American College of Emergency Physicians Open. 3 (4). doi:10.1002/emp2.12769.
  2. 1 2 Mewasingh, Leena D; Chin, Richard F M; Scott, Rod C (November 2020). "Current understanding of febrile seizures and their long‐term outcomes". Developmental Medicine & Child Neurology. 62 (11): 1245–1249. doi:10.1111/dmcn.14642.
  3. ↑ Wiebe S, et al. (2001). "A randomized, controlled trial of surgery for temporal lobe epilepsy". NEJM. 345 (5): 311–318. doi:10.1056/NEJM200108023450501. PMID 11484687. S2CID 31539171.
  4. ↑ Cheung; et al. (2009). "Pre- and postoperative fMRI and clinical memory performance in temporal lobe epilepsy". J Neurol Neurosurg Psychiatry. 80 (10): 1099–1106. doi:10.1136/jnnp.2009.173161. hdl:10397/33373. PMID 19389718. S2CID 5602939.
  5. ↑ Maccotta L, et al. (2007). "Changing frontal contributions to memory before and after medial temporal lobectomy". Cereb Cortex. 17 (2): 443–456. doi:10.1093/cercor/bhj161. PMID 16547345.
  6. ↑ Helmstaedter C, et al. (2008). "The effects of cognitive rehabilitation on memory outcome after temporal lobe epilepsy surgery". Epilepsy Behav. 12 (3): 402–409. doi:10.1016/j.yebeh.2007.11.010. PMID 18155965. S2CID 29690584.
  7. ↑ Curry, Daniel J.; Gowda, Ashok; McNichols, Roger J.; Wilfong, Angus A. (2012). "MR-guided stereotactic laser ablation of epileptogenic foci in children". Epilepsy & Behavior. 24 (4): 408–414. doi:10.1016/j.yebeh.2012.04.135. PMID 22687387. S2CID 531323.
  8. ↑ Freeman, JM; Kossoff, EH; Hartman, AL (March 2007). "The ketogenic diet: one decade later". Pediatrics. 119 (3): 535–43. doi:10.1542/peds.2006-2447. PMID 17332207. S2CID 26629499.
  9. ↑ Rezaei, Shahabeddin; Abdurahman, Ahmed Abdulahi; Saghazadeh, Amene; Badv, Reza Shervin; Mahmoudi, Maryam (4 May 2019). "Short-term and long-term efficacy of classical ketogenic diet and modified Atkins diet in children and adolescents with epilepsy: A systematic review and meta-analysis". Nutritional Neuroscience. 22 (5): 317–334. doi:10.1080/1028415X.2017.1387721.
  10. ↑ Ramachandran, V. and Blakeslee (1998). Phantoms in the Brain.
  11. 1 2 Craig Aaen-Stockdale (2012). "Neuroscience for the Soul". The Psychologist. 25 (7): 520–523. Archived from the original on 26 October 2015.
  12. ↑ Tedrus, Glória Maria Almeida Souza; Fonseca, Lineu Corrêa; Fagundes, Tatiane Mariani; da Silva, Gabriela Leopoldino (2015). "Religiosity aspects in patients with epilepsy". Epilepsy & Behavior. 50: 67–70. doi:10.1016/j.yebeh.2015.06.003. PMID 26133113. S2CID 22703938.
  13. ↑ Tedrus, Glória Maria Almeida Souza; Fonseca, Lineu Corrêa; Höehr, Gabriela Chaves (2013). "Spirituality aspects in patients with epilepsy". Seizure. 23 (1): 25–8. doi:10.1016/j.seizure.2013.09.005. PMID 24094727. Patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) had significantly higher SSRS scores than those with other epileptic syndromes and, than in individuals of the CG (control Group)
  14. ↑ d'Orsi, Giuseppe; Tinuper, Paolo (2006). ""I heard voices*": from semiology, a historical review, and a new hypothesis on the presumed epilepsy of Joan of Arc". Epilepsy & Behavior. 9 (1): 152–157. doi:10.1016/j.yebeh.2006.04.020. PMID 16750938. S2CID 24961015.
  15. ↑ Murray E. D.; et al. (2012). "The role of psychotic disorders in religious history considered". The Journal of Neuropsychiatry and Clinical Neurosciences. 24 (4): 410–426. doi:10.1176/appi.neuropsych.11090214. PMID 23224447. S2CID 207654711.
  16. ↑ Sirven, Joseph I; Drazkowski, Joseph F; Noe, Katherine H (2007). "Seizures among public figures: lessons learned from the epilepsy of Pope Pius IX". Mayo Clinic Proceedings. 82 (12): 1535–1540. doi:10.1016/S0025-6196(11)61100-2. PMID 18053463.
  17. ↑ Arzy, S; Schurr, R (July 2016). ""God has sent me to you": Right temporal epilepsy, left prefrontal psychosis". Epilepsy & Behavior. 60: 7–10. doi:10.1016/j.yebeh.2016.04.022. PMID 27176877. S2CID 3886939.
  18. 1 2 Benson, D.F. & Hermann, B.P. (1998) Personality disorders. In J. Engel Jr. & T.A. Pedley (Eds.) Epilepsy: A comprehensive textbook. Vol. II (pp. 2065–2070). Philadelphia: Lippincott–Raven.
  19. ↑ Tedrus, Glória Maria Almeida Souza; Fonseca, Lineu Corrêa; Fagundes, Tatiane Mariani; da Silva, Gabriela Leopoldino (2015). "Religiosity aspects in patients with epilepsy". Epilepsy & Behavior. 50: 67–70. doi:10.1016/j.yebeh.2015.06.003. PMID 26133113. S2CID 22703938.
  20. ↑ Tedrus, Glória Maria Almeida Souza; Fonseca, Lineu Corrêa; Höehr, Gabriela Chaves (2013). "Spirituality aspects in patients with epilepsy". Seizure. 23 (1): 25–8. doi:10.1016/j.seizure.2013.09.005. PMID 24094727. Patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) had significantly higher SSRS scores than those with other epileptic syndromes and, than in individuals of the CG (control Group)
  21. ↑ d'Orsi, Giuseppe; Tinuper, Paolo (2006). ""I heard voices*": from semiology, a historical review, and a new hypothesis on the presumed epilepsy of Joan of Arc". Epilepsy & Behavior. 9 (1): 152–157. doi:10.1016/j.yebeh.2006.04.020. PMID 16750938. S2CID 24961015.
  22. ↑ Murray E. D.; et al. (2012). "The role of psychotic disorders in religious history considered". The Journal of Neuropsychiatry and Clinical Neurosciences. 24 (4): 410–426. doi:10.1176/appi.neuropsych.11090214. PMID 23224447. S2CID 207654711.
  23. ↑ Sirven, Joseph I; Drazkowski, Joseph F; Noe, Katherine H (2007). "Seizures among public figures: lessons learned from the epilepsy of Pope Pius IX". Mayo Clinic Proceedings. 82 (12): 1535–1540. doi:10.1016/S0025-6196(11)61100-2. PMID 18053463.
  24. ↑ Arzy, S; Schurr, R (July 2016). ""God has sent me to you": Right temporal epilepsy, left prefrontal psychosis". Epilepsy & Behavior. 60: 7–10. doi:10.1016/j.yebeh.2016.04.022. PMID 27176877. S2CID 3886939.

TMM53 (talk) 06:56, 19 April 2023 (UTC)Reply

Pathophysiology section uses primary sources, outdated information, needs rewrite.

[edit]
Latest comment: 3 years ago1 comment1 person in discussion

The pathophysiology section is based all on primary sources which is not recommended for medical articles Wikipedia:Identifying reliable sources (medicine). Some of the mechanisms have been shown to be invalid e.g. dormant basket cell and granule cell dispersion. Also, Human herpes virus 6 and Reelin have very limited evidence for being significant and should not be included. I will rewrite using secondary sources and retain as much as possible. Any thoughts, then please respond.

Dormant basket cell not considered valid:

Granule cell dispersion occurs in many people without epilepsy:

  • Roy, Achira; Millen, Kathleen J.; Kapur, Raj P. (2020). "Hippocampal granule cell dispersion: a non-specific finding in pediatric patients with no history of seizures". Acta Neuropathologica Communications. 8 (1): 54. doi:10.1186/s40478-020-00928-3.{{cite journal}}: CS1 maint: unflagged free DOI (link)

TMM53 (talk) 06:23, 5 June 2023 (UTC)Reply

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