Talk:Sphingosine
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[edit]This section says that dehydrosphingosine (usually called 3-ketosphinganine) is enzymatically converted to sphingosine but it isn't. The carbonyl group is reduced, forming dihydrosphingosine (sphinganine), which reacts with a fatty acid-CoA, forming dihydroceramide, which is then dehydrogenated to form the trans double bond at carbons 4 and 5. This is ceramide, which can be hydrolyzed to liberate sphingosine and fatty acid.
Image Sphingosine synthesis corrected.png: Error
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In the Biosynthesis section the image Sphingosine synthesis corrected.png depicts serine with an amine group on the secondary carbon and a hydroxyl group on a primary carbon. In the true structure of serine an hydroxyl group is on the secondary carbon and an amine group on the primary carbon.
- The chemical structure of serine in File:Sphingosine synthesis corrected.png appears to be correct to me. It is incorrect to say that in serine a hydroxyl group is on the secondary carbon and an amine group is on the primary carbon - compare with the diagram in the article serine. -- Ed (Edgar181) 19:38, 10 August 2012 (UTC)
Biosynthesis
[edit]The Biosynthesis section needs citations from sources verifying the information. --Djinn32 (talk) 00:33, 4 October 2019 (UTC)